ArticleActa psychiatrica Scandinavica2017
Global brain asymmetry is increased in schizophrenia and related to avolition.
Article in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Gray Matter Asymmetry Alterations in Patients With Spinocerebellar Ataxia Type 3: A Voxel-Based Morphometric Comparison Study.CNS neuroscience & therapeutics · 2024Article
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- A multiscale characterization of cortical shape asymmetries in early psychosis.Brain communications · 2024Article
- Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder.Journal of clinical medicine · 2023Article
- Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia.Journal of personalized medicine · 2022Article
- Negative symptoms correlate with altered brain structural asymmetry in amygdala and superior temporal region in schizophrenia patients.Frontiers in psychiatry · 2022Article
- Abnormal Cortical Activation Patterns Among Chinese-Speaking Schizophrenia Patients During Category and Letter Verbal Fluency Tasks Revealed by Multi-Channel Functional Near-Infrared Spectroscopy.Frontiers in psychiatry · 2021Article
- Comparison of frontal alpha asymmetry among schizophrenia patients, major depressive disorder patients, and healthy controls.BMC psychiatry · 2020Article
- Frontotemporal asymmetry in socioemotional behavior: A pilot study in frontotemporal dementia.Social neuroscience · 2020Article
- Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease.Frontiers in neurology · 2020Article
- Visuospatial task-related prefrontal activity is correlated with negative symptoms in schizophrenia.Scientific reports · 2019Article
- Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial.Schizophrenia research. Cognition · 2018Article
- Asymmetric Drug-Induced Parkinsonism and Psychopathology: A Prospective Naturalistic Study in Long-Stay Psychiatric Patients.Frontiers in psychiatry · 2018Article
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8 authors.
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Abstract
objectiveSchizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole-brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres.
methodGlobal gray and white matter asymmetry was calculated from high-resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age- and sex-matched. Some of the analyses were replicated in a much larger sample (n = 759) obtained from open-access online databases.
resultsPatients with schizophrenia had more global gray matter asymmetry than controls. Additionally, increased gray matter asymmetry was associated with avolition, whereas the inverse relationship was found for anxiety at a trend level. These analyses were replicated in a larger sample and confirmed previous results.
conclusionOur findings suggest that global gray matter asymmetry is related to the concept of developmental stability and is a useful indicator of perturbations during neurodevelopment.
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