ArticleScientific reports2017
B lymphocytes play a limited role in clearance of Campylobacter jejuni from the chicken intestinal tract.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Evaluation of Two Recombinant Protein-Based Vaccine Regimens againstAnimals : an open access journal from MDPI · 2023Article
- First report of phenotypic and genotypic (blaVeterinary world · 2023Article
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- IgYs: on her majesty's secret service.Frontiers in immunology · 2023Review
- Impact of DNA Prime/Protein Boost Vaccination againstVaccines · 2022Article
- Live-Attenuated Oral Vaccines to ReduceVaccines · 2022Article
- The Use of Probiotics in the Reduction ofAnimals : an open access journal from MDPI · 2021Review
- A Systematic Review ofMicroorganisms · 2021Review
- The ProbioticAnimals : an open access journal from MDPI · 2021Article
- Characterizing the immune response of chickens to Campylobacter jejuni (Strain A74C).PloS one · 2021Article
- Improving Chicken Responses to Glycoconjugate Vaccination AgainstFrontiers in microbiology · 2021Article
- Article
- Current Perspectives and Potential of Probiotics to Limit FoodborneFrontiers in microbiology · 2020Review
- Human Immunity AgainstImmune network · 2019Review
- Infectious bursal disease virus inoculation infection modifiesGut pathogens · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis with contaminated poultry meat its main source. Control of C. jejuni is a priority for the poultry industry but no vaccines are available and their development hampered by poor understanding of the immunobiology of C. jejuni infection. Here we show the functional role of B lymphocytes in response to C. jejuni in the chicken through depletion of the B lymphocyte population (bursectomy) followed by challenge. B lymphocyte depletion has little effect on bacterial numbers in the ceca, the main site of colonisation, where C. jejuni persist to beyond commercial slaughter age, but reduces clearance from the small intestine. In longer-term experiments we show antibody leads to reduction in C. jeuni numbers in the ceca by nine weeks post infection. Whilst we did not examine any protective role to re-challenge, it illustrates the difficulty in producing a vaccine in a young, immunologically naïve host. We believe this is first study of functional immunity to C. jejuni in chicken and shows antibody is ineffective in clearing C. jejuni from the ceca within the production lifetime of chickens, although is involved in clearance from the small intestine and longer-term clearance from the ceca.
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Registered trials
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