Evidence map›Paper›PMID 28332596›Full record

ArticleScientific reports2017

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance.

Benjamin J Jenkins, Kevin Seyssel, Sally Chiu, Pin-Ho Pan, Shih-Yi Lin, Elizabeth Stanley, Zsuzsanna Ament, James A West, Keith Summerhill, Julian L Griffin and 17 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 3 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Ca:Mg ratio, medium-chain fatty acids, and the gut microbiome.Clinical nutrition (Edinburgh, Scotland) · 2022
    Trial
  6. Trial
  7. Article
  8. Article
  9. A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Phylogenetic Aspects of Higher Plant Lipid Fatty Acid Profile.International journal of molecular sciences · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 7 countries.

Benjamin J JenkinsMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Kevin SeysselLyon University, INSERM U1060, CarMeN Laboratory and CENS, Claude Bernard University, CRNH Rhône-Alpes, Centre Hospitalier Lyon-Sud, 69310, Pierre-Bénite, France.
Sally ChiuChildren's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, United States of America.
Pin-Ho PanDepartment of Pediatrics, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan.
Shih-Yi LinDivision of Endocrinology and Metabolism/Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Taichung 407, Taiwan.
Elizabeth StanleyMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Zsuzsanna AmentMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
James A WestMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Keith SummerhillMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Julian L GriffinMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Walter VetterUniversity of Hohenheim, Institute of Food Chemistry, Garbenstrasse 28, D-70599 Stuttgart, Germany.
Kaija J AutioFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, FI-90014, Finland.
Kalervo HiltunenFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, P.O. Box 5400, FI-90014, Finland.
Stéphane HazebrouckUMR CEA-INRA Service de Pharmacologie et d'Immunoanalyse, Laboratoire d'Immuno-Allergie Alimentaire, Université Paris-Saclay, F-91991 Gif-sur-Yvette, France.
Renata StepankovaLaboratory of Gnotobiology, Institute of Microbiology, Czech Academy of Science, Novy Hradek, 549 22, Prague, Czech Republic.
Chun-Jung ChenDepartment of Medical Research, Taichung Veterans General Hospital, No. 1650, Sec.4, Taiwan Boulevard, Taichung 407, Taiwan.
Maud AlligierLyon University, INSERM U1060, CarMeN Laboratory and CENS, Claude Bernard University, CRNH Rhône-Alpes, Centre Hospitalier Lyon-Sud, 69310, Pierre-Bénite, France.
Martine LavilleLyon University, INSERM U1060, CarMeN Laboratory and CENS, Claude Bernard University, CRNH Rhône-Alpes, Centre Hospitalier Lyon-Sud, 69310, Pierre-Bénite, France.
Mary Moore702 Light Hall, Dept. of Molecular Physiology &Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, United States of America.
Guillaume Kraft702 Light Hall, Dept. of Molecular Physiology &Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, United States of America.
Alan Cherrington702 Light Hall, Dept. of Molecular Physiology &Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, United States of America.
Sarah KingChildren's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, United States of America.
Ronald M KraussChildren's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, United States of America.
Evelyn de SchryverLaboratory of Lipid Biochemistry and Protein Interactions (LIPIT), Campus Gasthuisberg - KU Leuven, Herestraat Box 601, B-3000 Leuven, Belgium.
Paul P Van VeldhovenLaboratory of Lipid Biochemistry and Protein Interactions (LIPIT), Campus Gasthuisberg - KU Leuven, Herestraat Box 601, B-3000 Leuven, Belgium.
Martin RonisCollege of Medicine, Department of Pharmacology &Experimental Therapeutics, Louisiana State University Health Sciences Centre 1901 Perdido Str., New Orleans, United States of America.
Albert KoulmanMedical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL. Affiliated with the University of Cambridge, United Kingdom.
Institute of Molecular Biology and Biophysics · RULaboratoire CarMeN · FRMRC Human Nutrition Research · GBUniversity of Cambridge · GBBiocenter Finland · FICzech Academy of Sciences, Institute of Microbiology · CZMedical Research Council · GBTungs' Taichung MetroHarbor Hospital · TWUniversity of Hohenheim · DE

Funding

GLUCONEOGENESIS &GLYCOGENOLYSIS:ROLE &REGULATIONR01DK018243 · NIDDK · VANDERBILT UNIVERSITY · PI Alan D Cherrington, Dale S Edgerton · 1986 to 2026
$12.2M
Medical Research Council MC_EX_G0800783Medical Research Council MC_PC_13030Medical Research Council MC_UP_A090_1006Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1Medical Research Council UD99999906NIDDK NIH HHS R01 DK018243
6 · The paper itself

Abstract

Recent findings have shown an inverse association between circulating C15:0/C17:0 fatty acids with disease risk, therefore, their origin needs to be determined to understanding their role in these pathologies. Through combinations of both animal and human intervention studies, we comprehensively investigated all possible contributions of these fatty acids from the gut-microbiota, the diet, and novel endogenous biosynthesis. Investigations included an intestinal germ-free study and a C15:0/C17:0 diet dose response study. Endogenous production was assessed through: a stearic acid infusion, phytol supplementation, and a Hacl1

Indexed as

Gastrointestinal MicrobiomeGlucose IntoleranceAnimalsBiosynthetic PathwaysDietDietary FatsDietary SugarsDietary SupplementsFatty AcidsGlucose Tolerance TestHumansMiceRatsDietary FatsDietary SugarsFatty Acids

Identifiers

PMID28332596
PMCPMC5362956
OpenAlexW2598624614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.