ArticleScientific reports2017
Pupillary responses in non-proliferative diabetic retinopathy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Multidimensional sleep health and diabetic retinopathy: Systematic review and meta-analysis.Sleep medicine reviews · 2024Pooled it
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Rod Pathway Dysfunction in Early-Stage Diabetic Retinopathy Assessed by ERG and Pupillometry.Investigative ophthalmology & visual science · 2026Article
- Machine learning-based prediction of diabetic retinopathy from pupillary abnormalities in a South Indian population.PloS one · 2026Article
- Circadian rhythm amplification in diabetic retinopathy: a pilot study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- A rapid pupillometry protocol for clinical use: effect of age and test-retest repeatability.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Association of Scheimpflug-based pupillometry with Severity of diabetic retinopathy and regulation of diabetes: A case-control study.International ophthalmology · 2025Article
- A rapid pupillometry protocol for clinical use: Effect of age and test-retest repeatability.Research square · 2025Article
- Uncovering the Characteristics of Pupil Cycle Time (PCT) in Neuropathies and Retinopathies.Vision (Basel, Switzerland) · 2025Article
- Frequency tagged multifocal pupillary response fields identify age-related macular degeneration and diabetic retinopathy.Frontiers in neuroscience · 2025Article
- Basics, benefits, and pitfalls of pupillometers assessing visual function.Eye (London, England) · 2024Review
- Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study.Diabetologia · 2024Article
- Evaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry.Ophthalmology and therapy · 2023Article
- Visual Field Abnormalities in Early-Stage Diabetic Retinopathy Assessed by Chromatic Perimetry.Investigative ophthalmology & visual science · 2023Article
- Retinal neural dysfunction in diabetes revealed with handheld chromatic pupillometry.Clinical & experimental ophthalmology · 2022Article
- Melanopsin photoreception differentially modulates rod-mediated and cone-mediated human temporal vision.iScience · 2022Article
- Alterations of color vision and pupillary light responses in age-related macular degeneration.Frontiers in aging neuroscience · 2022Article
- Supplemental light exposure improves sleep architecture in people with type 2 diabetes.Acta diabetologica · 2021Article
- Using System Identification to Construct an Inherent Model of Pupillary Light Reflex to Explore Diabetic Neuropathy.Brain sciences · 2021Article
- Sleep variability, 6-sulfatoxymelatonin, and diabetic retinopathy.Sleep & breathing = Schlaf & Atmung · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The goal of this study was to determine the extent of rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative diabetic retinopathy (NPDR). Fifty diabetic subjects who have different stages of NPDR and 25 age-equivalent, non-diabetic controls participated. PLRs were measured in response to full-field, brief-flash stimuli under conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways. Pupil responses were compared among the subjects groups using age-corrected linear mixed models. Compared to control, the mean baseline pupil diameters were significantly smaller for all patient groups in the dark (all p < 0.001) and for the moderate-severe NPDR group in the light (p = 0.003). Pairwise comparisons indicated: (1) the mean melanopsin-mediated PLR was significantly reduced in the mild and moderate-severe groups (both p < 0.001); (2) the mean cone-mediated PLR was reduced significantly in the moderate-severe group (p = 0.008); (3) no significant differences in the mean rod-mediated responses. The data indicate abnormalities in NPDR patients under conditions that separately assess pupil function driven by different photoreceptor classes. The results provide evidence for compromised neural function in these patients and provide a promising approach for quantifying their neural abnormalities.
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Registered trials
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