Evidence map›Paper›PMID 28332560›Full record

ArticleGenes and immunity2017

Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.

D D Cyr, A S Allen, G-J Du, F Ruffin, C Adams, J T Thaden, S A Maskarinec, M Souli, S Guo, D M Dykxhoorn and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Genes and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Frontiers in microbiomes · 2024
    Article
  6. Persistent Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Frontiers in cellular and infection microbiology · 2022
    Review
  11. Review
  12. Review
  13. Risk Factors for Recurrent Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  14. Evasion of Immunological Memory byFrontiers in immunology · 2021
    Review
  15. Article
  16. Article
  17. Variable Release of Lipoteichoic Acid FromFrontiers in microbiology · 2020
    Article
  18. Review
  19. Article
  20. Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

D D CyrDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
A S AllenDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
G-J DuDuke Center for Genomic and Computational Biology, Durham, NC, USA.
F RuffinDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
C AdamsDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
J T ThadenDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
S A MaskarinecDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
M SouliDivision of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.
S GuoDr John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
D M DykxhoornDr John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
W K ScottDr John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL, USA.
V G FowlerDuke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · USUniversity of Miami · USClinical Research Institute · USDr. John T. Macdonald Foundation · USDuke University · USNational and Kapodistrian University of Athens · GRNorth Carolina Biotechnology Center · US

Funding

Host Susceptibility to S. aureusR01AI068804 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2007 to 2016
$6.9M
NIAID NIH HHS R01 AI068804
6 · The paper itself

Abstract

The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ

Indexed as

Genetic Predisposition to DiseaseBacteremiaBlack or African AmericanHumansIncidencePolymorphism, Single NucleotideStaphylococcal InfectionsStaphylococcus aureus

Identifiers

PMID28332560
PMCPMC5435963
OpenAlexW2597585344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.