ArticleInfection & chemotherapy2017
High Incidence of Virulence Factors Among Clinical Enterococcus faecalis Isolates in Southwestern Iran.
Article in Infection & chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 46 citations in OpenAlex.
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- Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci.Antibiotics (Basel, Switzerland) · 2020Article
- Improved detection of esp, hyl, asa1, gelE, cylA virulence genes among clinical isolates of Enterococci.BMC research notes · 2020Article
- Genetic relatedness of theGut pathogens · 2020Article
- Evaluation of Blood and Liver Cytotoxicity and Apoptosis-necrosis Induced by Nanochelating Based Silver Nanoparticles in Mouse Model.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Phenotypic and genotypic characterization of glycopeptide, aminoglycoside and macrolide resistance among clinical isolates of Enterococcus faecalis: a multicenter based study.BMC research notes · 2019Article
- Molecular Characterization Of Vancomycin-ResistantInfection and drug resistance · 2019Article
- A Novel Detection ofInfection and drug resistance · 2019Article
- Production of Membrane Vesicles byFrontiers in cellular and infection microbiology · 2019Article
- Rise of antibiotic resistance in clinical enterococcal isolates during 2001-2016 in Iran: a review.New microbes and new infections · 2018Review
- Detection of Antimicrobial Susceptibility and Integrons Among Extended-spectrum β-lactamase Producing UropathogenicOman medical journal · 2018Article
- Bacteriostatic Potency of FeAvicenna journal of medical biotechnologyArticle
- Emergence of High-level Gentamicin Resistance amongPolish journal of microbiologyArticle
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4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the past two decades, enterococci have emerged as an important agent responsible for hospital acquired infection. Several virulence factors contribute to the adherence, colonization, evasion of the host immune response, and pathogenicity and severity of the infection. Enterococcus faecalis is the most common and virulent species causing infections in hospitalized patients. The aim of the present study was to examine the prevalence of genes encoding virulence factors and antimicrobial resistance patterns of E. faecalis strains isolated from hospitalized patients in Shiraz, south west of Iran. MATERIALS AND
methodsA total of 51 E. faecalis isolates from the urine, blood, pleural fluid, peritoneal fluid, eye discharge, endotracheal tube (ETT) and transjugular intrahepatic portosystemic shunt (TIPS) specimens of patients were identified by phenotypic and genotypic methods. Antimicrobial sensitivity tests and detection of virulence factors were performed using standard methods.
resultsThe efa and asa1 were the most frequently detected gene (100%) among the isolates, followed by esp (94.1%), ace (90.2%), gelE (80.4%), cylA (64.7%), and hyl (51%). More than half of the isolates (52.9%) were high level gentamicin resistant (HLGR). Vancomycin resistance was observed among 23 (45.1%) isolates. The lowest antimicrobial activity was related to erythromycin (3.9%), tetracycline (5.9%) and ciprofloxacin (9.8%). No isolate was found resistant to fosfomycin and linezolid.
conclusionOur data indicated a high incidence of virulence factors among E. faecalis strains isolated from clinical samples. Colonization of drug resistant virulent isolates in hospital environment may lead to life threatening infection in hospitalized patients. Therefore, infection control procedures should be performed.
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