ArticlePlant biotechnology journal2017
Time-course expression QTL-atlas of the global transcriptional response of wheat to Fusarium graminearum.
Article in Plant biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Two major quantitative trait loci control wheat dwarf virus resistance in four related winter wheat populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Molecular mechanisms underpinning quantitative resistance toFrontiers in plant science · 2023Article
- Fusarium head blight resistance in European winter wheat: insights from genome-wide transcriptome analysis.BMC genomics · 2021Article
- Merging Genomics and Transcriptomics for Predicting Fusarium Head Blight Resistance in Wheat.Genes · 2021Article
- FightingPathogens (Basel, Switzerland) · 2020Article
- Characterization of QTL and eQTL controlling early Fusarium graminearum infection and deoxynivalenol levels in a Wuhan 1 x Nyubai doubled haploid wheat population.BMC plant biology · 2019Article
- Genetic factors affecting Fusarium head blight resistance improvement from introgression of exotic Sumai 3 alleles (including Fhb1, Fhb2, and Fhb5) in hard red spring wheat.BMC plant biology · 2019Article
- A multiple near isogenic line (multi-NIL) RNA-seq approach to identify candidate genes underpinning QTL.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Transcriptomics of cereal-Fusarium graminearum interactions: what we have learned so far.Molecular plant pathology · 2018Review
- Identification, Molecular Cloning, and Functional Characterization of a Wheat UDP-Glucosyltransferase Involved in Resistance to Fusarium Head Blight and to Mycotoxin Accumulation.Frontiers in plant science · 2018Article
- Integrated QTL and eQTL Mapping Provides Insights and Candidate Genes for Fatty Acid Composition, Flowering Time, and Growth Traits in a FFrontiers in plant science · 2018Article
- Interchromosomal Transfer of Immune Regulation During Infection of Barley with the Powdery Mildew Pathogen.G3 (Bethesda, Md.) · 2017Article
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5 authors.
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Abstract
Fusarium head blight is a devastating disease of small grain cereals such as bread wheat (Triticum aestivum). The pathogen switches from a biotrophic to a nectrotrophic lifestyle in course of disease development forcing its host to adapt its defence strategies. Using a genetical genomics approach, we illustrate genome-wide reconfigurations of genetic control over transcript abundances between two decisive time points after inoculation with the causative pathogen Fusarium graminearum. Whole transcriptome measurements have been recorded for 163 lines of a wheat doubled haploid population segregating for several resistance genes yielding 15 552 at 30 h and 15 888 eQTL at 50 h after inoculation. The genetic map saturated with transcript abundance-derived markers identified of a novel QTL on chromosome 6A, besides the previously reported QTL Fhb1 and Qfhs.ifa-5A. We find a highly different distribution of eQTL between time points with about 40% of eQTL being unique for the respective assessed time points. But also for more than 20% of genes governed by eQTL at either time point, genetic control changes in time. These changes are reflected in the dynamic compositions of three major regulatory hotspots on chromosomes 2B, 4A and 5A. In particular, control of defence-related biological mechanisms concentrated in the hotspot at 4A shift to hotspot 2B as the disease progresses. Hotspots do not colocalize with phenotypic QTL, and within their intervals no higher than expected number of eQTL was detected. Thus, resistance conferred by either QTL is mediated by few or single genes.
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