ReviewSports medicine (Auckland, N.Z.)2017
Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments.
Review in Sports medicine (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Does mechanical loading restore ligament biomechanics after injury? A systematic review of studies using animal models.BMC musculoskeletal disorders · 2023Pooled it
- Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults.Journal of the International Society of Sports Nutrition · 2023Trial
- Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men.Nutrients · 2019Trial
- Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate-A Randomized Controlled Trial.Nutrients · 2019Trial
- The effects of Shilajit supplementation on fatigue-induced decreases in muscular strength and serum hydroxyproline levels.Journal of the International Society of Sports Nutrition · 2019Trial
- Review
- Rehabilitation Nutrition for Tendon and Ligament Injuries: From Collagen Remodeling to Return-to-Activity and Sport.Healthcare (Basel, Switzerland) · 2026Review
- Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.Matrix biology plus · 2025Article
- ACL Pacinian mechanoreceptors: Conceptualizing a vasoregulatory microtrauma healing function.Journal of experimental orthopaedics · 2025Article
- Effects of Different Loading Programs on Finger Strength in Rock Climbers.Sports medicine - open · 2024Article
- Regenerative Anterior Cruciate Ligament Healing in Youth and Adolescent Athletes: The Emerging Age of Recovery Science.Journal of functional morphology and kinesiology · 2024Review
- Characterization of anMatrix biology plus · 2024Article
- Novel Orthobiologic Preparation and Regenerative Rehabilitation of a Complex Shoulder Injury in a Competitive Adolescent Female Athlete.International journal of sports physical therapy · 2023Article
- ACL microtrauma: healing through nutrition, modified sports training, and increased recovery time.Journal of experimental orthopaedics · 2022Review
- Using Long-Duration Static Stretch Training to Counteract Strength and Flexibility Deficits in Moderately Trained Participants.International journal of environmental research and public health · 2022Article
- Sex-Specific Changes in Physical Risk Factors for Anterior Cruciate Ligament Injury by Chronological Age and Stages of Growth and Maturation From 8 to 18 Years of Age.Journal of athletic training · 2022Article
- The top 100 most impactful articles on the anterior cruciate ligament: An altmetric analysis of online media.SAGE open medicine · 2022Article
- Review
- Potential Relevance of Bioactive Peptides in Sports Nutrition.Nutrients · 2021Review
- The importance of plasmin for the healing of the anterior cruciate ligament.Bone & joint research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal injuries account for more than 70% of time away from sports. One of the reasons for the high number of injuries and long return to play is that we have only a very basic understanding of how our training alters tendon and ligament (sinew) structure and function. Sinews are highly dense tissues that are difficult to characterize both in vivo and in vitro. Recently, engineered ligaments have been developed in vitro using cells from human anterior cruciate ligaments or hamstring tendons. These three-dimensional tissues can be grown in a laboratory, treated with agents thought to affect sinew physiology, and then mechanically tested to determine their function. Using these tissues, we have learned that sinews, like bone, quickly become refractory to an exercise stimulus, suggesting that short (<10 min) periods of activity with relatively long (6 h) periods of rest are best to train these tissues. The engineered sinews have also shown how estrogen decreases sinew function and that a factor released following intense exercise increases sinew collagen synthesis and function. Last, engineered sinews are being used to screen possible nutritional interventions that may benefit tendon or ligament function. Using the data derived from these tissue-engineered sinews, new nutritional and training regimes are being designed and tested with the goal of minimizing injury and accelerating return to play.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.