ArticlePituitary2017
White matter involvement on DTI-MRI in Cushing's syndrome relates to mood disturbances and processing speed: a case-control study.
Article in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Prospective Assessment of Mood and Quality of Life in Cushing Syndrome Before and After Biochemical Control.The Journal of clinical endocrinology and metabolism · 2026Observational
- Potential mechanisms of the glucocorticoid withdrawal syndrome.European journal of endocrinology · 2026Review
- Comparative Analysis of Cognitive and Psychiatric Functioning in People With Cushing's Disease in Biochemical Remission and People With Nonfunctioning Adenomas.Behavioural neurology · 2024Article
- Reversibility of Impaired Large-Scale Functional Brain Networks in Cushing's Disease after Surgery Treatment: A Longitudinal Study.Neuroendocrinology · 2024Article
- Dynamic functional connectivity changes associated with psychiatric traits and cognitive deficits in Cushing's disease.Translational psychiatry · 2023Article
- Glucocorticoids and cognitive function: a walkthrough in endogenous and exogenous alterations.Journal of endocrinological investigation · 2023Review
- Article
- Long-term effects of glucocorticoid excess on the brain.Journal of neuroendocrinology · 2022Review
- Altered microstructural pattern of white matter in Cushing's disease identified by automated fiber quantification.NeuroImage. Clinical · 2021Article
- Evaluation of Nurses' and Patients' Overall Satisfaction with New and Previous Formulations of Octreotide Long-acting Release (Sandostatin LARAdvances in therapy · 2020Observational
- The association between physical activity, sleep, and quality of life in patients in bio-chemical remission from Cushing's syndrome.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Detrimental effects of hypercortisolism on brain structure and related risk factors.Scientific reports · 2020Article
- Computerized Analysis of Brain MRI Parameter Dynamics in Young Patients With Cushing Syndrome-A Case-Control Study.The Journal of clinical endocrinology and metabolism · 2020Article
- Neuropsychological and Emotional Functioning in Patients with Cushing's Syndrome.Behavioural neurology · 2020Article
- Quality of Life in Patients With Cushing's Disease.Frontiers in endocrinology · 2019Review
- Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study.Neurology · 2018Article
- Lack of functional remission in Cushing's syndrome.Endocrine · 2018Observational
- Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma.European journal of endocrinology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCushing's syndrome (CS) is an endocrine disorder due to prolonged exposure to cortisol. Recently, microstructural white matter (WM) alterations detected by diffusion tensor imaging (DTI) have been reported in CS patients, and related to depression, but other functional significances. remain otherwise unclear. We aimed at investigating in more depth mood symptoms in CS patients, and how these relate to cognition (information processing speed), and to WM alterations on DTI.
methodsThe sample comprised 35 CS patients and 35 healthy controls. Beck Depression Inventory-II (BDI-II) was used to measure depressive symptoms, State-Trait Anxiety Inventory (STAI) to assess anxiety, and processing speed was measured by the Symbol Digit Modalities Test (SDMT). DTI studies were acquired using a 3-Tesla Philips-Achieva MR-facility. Voxelwise statistical analysis of fractional anisotropy (FA), mean, axial and radial diffusivities (MD, AD, RD) data were performed using FMRIB Software Library. Correlation analysis were obtained between mood and processing speed variables, and FA, MD, AD and RD values, taking both CS patients and healthy controls.
resultsActive, controlled and cured CS patients showed greater depression (F = 12.4, p < 0.001), anxious state (F = 4.8, p = 0.005) and anxious trait (F = 9.6, p < 0.001) scores, than controls. Using the entire sample, depression scores correlated negatively to FA and positively to RD values. Although there were no differences in processing speed between groups, SDMT scores correlated positively to both FA and AD values.
conclusionsThere were greater depressive and anxious symptoms in CS patients than in healthy controls, but no difference in processing speed. However, DTI is related to depression and information processing speed in CS.
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