ArticleNeuroImage. Clinical2017
Anatomical brain difference of subthreshold depression in young and middle-aged individuals.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies.BMC psychiatry · 2025Pooled it
- Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.Human brain mapping · 2024Pooled it
- Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.Dialogues in clinical neuroscience · 2025Trial
- Pallidal beta power is associated with depression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Disrupted small-world architecture and altered default mode network topology of brain functional network in college students with subclinical depression.BMC psychiatry · 2025Article
- Neural basis of self-esteem: social cognitive and emotional regulation insights.Frontiers in neuroscience · 2025Article
- Brain Abnormalities During Self-Referential Task in Subthreshold Depression: A Near-Infrared Spectroscopy Study.Cureus · 2024Article
- Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.Brain imaging and behavior · 2024Article
- Topological differences of striato-thalamo-cortical circuit in functional brain network between premature ejaculation patients with and without depression.Brain and behavior · 2024Article
- The association between gray matter volume in the hippocampal subfield and antidepressant efficacy mediated by abnormal dynamic functional connectivity.Scientific reports · 2024Article
- Age exacerbates the negative effect of depression on executive functioning in racial and ethnic minorities.Research square · 2023Article
- Abnormal volumetric brain morphometry and cerebral blood flow in adolescents with depression.World journal of psychiatry · 2023Article
- Resting-state functional connectivity disruption between the left and right pallidum as a biomarker for subthreshold depression.Scientific reports · 2023Article
- Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth.Scientific reports · 2022Article
- Abnormal Dynamic Functional Connectivity of the Left Rostral Hippocampus in Predicting Antidepressant Efficacy in Major Depressive Disorder.Psychiatry investigation · 2022Article
- Functional activation of insula and dorsal anterior cingulate for conflict control against larger monetary loss in young adults with subthreshold depression: a preliminary study.Scientific reports · 2022Article
- Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms.BMC psychiatry · 2022Article
- Regional gray matter volume mediates the relationship between neuroticism and depressed emotion.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundSubthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research.
aimIn this study we investigated common volumetric brain changes in both young and middle-aged StD patients.
methodsTwo cohorts of StD patients, young and middle-aged, (
resultsVBM analysis found that: 1) compared with healthy controls, StD patients showed decreased gray matter volume (GMV) in the bilateral globus pallidus and precentral gyrus, as well as increased GMV in the left thalamus and right rostral anterior cingulate cortex/medial prefrontal cortex; 2) there is a significant association between Center for Epidemiological Studies Depression Scale scores and the bilateral globus pallidus (negative) and left thalamus (positive); 3) there is no interaction between age (young vs. middle-age) and group (StD vs. controls).
conclusionsOur findings indicate significant VBM brain changes in both young and middle-aged individuals with StD. Individuals with StD, regardless of age, may share common neural characteristics.
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