ArticleNeuroImage. Clinical2017
Altered functional brain connectivity in patients with visually induced dizziness.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04649268 (The Effect of Virtual Reality and DVD Optokinetic Stimulation Exposure on Visual Induced Dizziness Symptoms in Persons With a Vestibular Disorder), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Virtual Reality and DVD Optokinetic Stimulation Exposure on Visual Induced Dizziness Symptoms in Persons With a Vestibular Disorder
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Neuroimaging studies in persistent postural-perceptual dizziness and related disease: a systematic review.Journal of neurology · 2022Pooled it
- Differentiating Persistent Postural-Perceptual Dizziness from Anxiety Disorder Using Behavioral Responses to Complex Visual Environments.Journal of clinical medicine · 2026Article
- A Diagnostic Framework for the Management of Post-Concussion Visually Induced Dizziness: Recognising Postural and Visuoperceptual Subtypes Using an Optokinetic Balance Assessment.Brain sciences · 2026Article
- Expanded Spatiotemporal Concept of Cortical Visual-Vestibular Interaction in Humans: A fMRI Study on Visually Induced Motion Perception.Brain and behavior · 2026Article
- [Gait characteristics in patients with persistent postural-perceptual dizziness].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Article
- Evolution of Research on Persistent Postural-Perceptual Dizziness: A Bibliometric and Visualization Analysis from 1994 to 2025.Audiology research · 2026Review
- Vestibular-Visual Reweighting in Persistent Postural-Perceptual Dizziness: A Multilevel Resting-State fMRI Study.Neural plasticity · 2026Article
- The default space theory: a unified oscillatory framework for spatial orientation and balance.Frontiers in neuroscience · 2026Article
- Temporal visual processing deficits in post concussion syndrome.Scientific reports · 2025Article
- Functional brain activity in persistent postural-perceptual dizziness (PPPD) during galvanic vestibular stimulation reveals sensitization in the multisensory vestibular cortical network.Scientific reports · 2025Article
- Diagnostics and Group Therapy in Patients with Persistent Postural-Perceptual Dizziness and Anxiety Disorder: Biomarkers and Neurofunctional Correlates of Underlying Treatment Effects.Diagnostics (Basel, Switzerland) · 2025Article
- Abnormal neural circuits and altered brain network topological properties in patients with persistent postural-perceptual dizziness.Communications biology · 2025Article
- Altered Hippocampal Subfields Functional Connectivity in Benign Paroxysmal Positional Vertigo Patients With Residual Dizziness: A Resting-State fMRI Study.CNS neuroscience & therapeutics · 2024Article
- Brain Functional Alterations in Patients With Benign Paroxysmal Positional Vertigo Demonstrate the Visual-Vestibular Interaction and Integration.Brain and behavior · 2024Article
- A Proposed Mechanism for Visual Vertigo: Post-Concussion Patients Have Higher Gain From Visual Input Into Subcortical Gaze Stabilization.Investigative ophthalmology & visual science · 2024Article
- Altered parietal operculum cortex 2 functional connectivity in benign paroxysmal positional vertigo patients with residual dizziness: A resting-state fMRI study.CNS neuroscience & therapeutics · 2024Article
- Altered thalamus functional connectivity in patients with acute unilateral vestibulopathy: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Functional reorganization of intranetwork and internetwork connectivity in patients with Ménière's disease.Scientific reports · 2023Article
- Delay and Acceleration Threshold of Movement Perception in Patients Suffering from Vertigo or Dizziness.Brain sciences · 2023Article
- Concussed patients with visually induced dizziness exhibit increased ocular torsion and vertical vergence during optokinetic gaze-stabilization.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVestibular patients occasionally report aggravation or triggering of their symptoms by visual stimuli, which is called visually induced dizziness (VID). These patients therefore experience dizziness, discomfort, disorientation and postural unsteadiness. The underlying pathophysiology of VID is still poorly understood.
objectiveThe aim of the current explorative study was to gain a first insight in the underlying neural aspects of VID.
methodsWe included 10 VID patients and 10 healthy matched controls, all of which underwent a resting state fMRI scan session. Changes in functional connectivity were explored by means of the intrinsic connectivity contrast (ICC). Seed-based analysis was subsequently performed in visual and vestibular seeds.
resultsWe found a decreased functional connectivity in the right central operculum (superior temporal gyrus), as well as increased functional connectivity in the occipital pole in VID patients as compared to controls in a hypothesis-free analysis. A weaker functional connectivity between the thalamus and most of the right putamen was measured in VID patients in comparison to controls in a seed-based analysis. Furthermore, also by means of a seed-based analysis, a decreased functional connectivity between the visual associative area and the left parahippocampal gyrus was found in VID patients. Additionally, we found increased functional connectivity between thalamus and occipital and cerebellar areas in the VID patients, as well as between the associative visual cortex and both middle frontal gyrus and precuneus.
conclusionsWe found alterations in the visual and vestibular cortical network in VID patients that could underlie the typical VID symptoms such as a worsening of their vestibular symptoms when being exposed to challenging visual stimuli. These preliminary findings provide the first insights into the underlying functional brain connectivity in VID patients. Future studies should extend these findings by employing larger sample sizes, by investigating specific task-based paradigms in these patients and by exploring the implications for treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.