ArticleBMC hematology2017
Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial.
Article in BMC hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Potential Role of Gum Arabic as Fetal Hemoglobin Agent in Sudanese Sickle Cell Anemia Patients
Potential Role of Gum Arabic as Antioxidant and Anti-inflammatory Agent in Hemodialysis Patients
Efficacy of Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients : A Randomized, Double-blind, Two-armed Parallel-group, Placebo-controlled Phase II/III Study - Khartoum, Sudan
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Is There a Difference in Occurrence of Complications Between Adults With Hemoglobin SS and Hemoglobin SC Disease: An Extended Systematic Review.European journal of haematology · 2026Pooled it
- The Efficacy of Gum Arabic in Managing Diseases: A Systematic Review of Evidence-Based Clinical Trials.Biomolecules · 2023Pooled it
- Trial
- Effect of Gum Arabic (Acacia senegal) on C-reactive protein level among sickle cell anemia patients.BMC research notes · 2020Trial
- Gum Acacia-Dexamethasone Combination Attenuates Sepsis-Induced Acute Kidney Injury in Rats via Targeting SIRT1-HMGB1 Signaling Pathway and Preserving Mitochondrial Integrity.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Synergistic Antigenotoxic and Antioxidant Action of Gum Arabic and Eugenol in Rat Liver Following Induction of Colorectal Carcinogenesis.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management.Scientific reports · 2023Review
- The effect of kappa-carrageenan and gum Arabic on the production of guava-banana fruit leather.Journal of food science and technology · 2022Article
- Gum Arabic protects the rat heart from ischemia/reperfusion injury through anti-inflammatory and antioxidant pathways.Scientific reports · 2022Article
- Redox Balance in β-Thalassemia and Sickle Cell Disease: A Love and Hate Relationship.Antioxidants (Basel, Switzerland) · 2022Review
- Protective Action ofACS omega · 2021Article
- Sickle Cell Disease: Role of Oxidative Stress and Antioxidant Therapy.Antioxidants (Basel, Switzerland) · 2021Review
- The Ameliorative Role ofAntioxidants (Basel, Switzerland) · 2021Article
- Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature.International journal of nanomedicine · 2021Review
- Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Acute and subacute oral toxicity assessment of dry encapsulated and non-encapsulated green coffee fruit extracts.Journal of food and drug analysis · 2020Article
- Gum Arabic (International journal of nephrology · 2020Article
- Decoding the role of SOD2 in sickle cell disease.Blood advances · 2019Review
- Biochemical effects and safety of Gum arabic (Blood research · 2019Article
- Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane1.Acta cirurgica brasileira · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats. We hypothesized that regular intake of GA increases anti-oxidant capacity and reduce oxidative stress.
methodsForty-seven patients (5-42 years) carrying hemoglobin SS were recruited. Patients received 30 g/day GA for 12 weeks. Total anti-oxidant capacity (TAC), malondialdehyde (MDA) and hydrogen peroxide (H
resultsGum Arabic significantly increased TAC level
conclusionsGA has potent anti- oxidative properties in sickle cell anemia. The anti-oxidant effect of GA may thus favorably influence the clinical condition of this and further diseases characterized by oxidative stress.
trial registrationClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. Retrospective registration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.