ArticleDiabetology & metabolic syndrome2017
Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction.
Article in Diabetology & metabolic syndrome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- An indicator of antioxidant stress ability to evaluate neurofunctional changes in patients with acute ischemic stroke: preliminary findings.BMC neurology · 2025Article
- Examination of Genetic and Epigenetic Characteristics of Patients with Hyperhomocysteinemia Following High-Dose Folic Acid Consumption.Nutrients · 2025Article
- Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Review
- Association between homocysteine levels and mortality in CVD: a cohort study based on NHANES database.BMC cardiovascular disorders · 2024Article
- Homocysteine levels are associated with diabetes mellitus in Chinese with H-type hypertension.Nutrition research and practice · 2024Article
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2023Review
- A Liquid Biopsy-Based Approach for Monitoring Treatment Response in Post-Operative Colorectal Cancer Patients.International journal of molecular sciences · 2022Article
- Longitudinal Analysis of 1α,25-dihidroxyvitamin DCancers · 2022Article
- A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction.Journal of medical biochemistry · 2021Article
- A high methionine and low folate diet alters glucose homeostasis and gut microbiome.Biochemistry and biophysics reports · 2021Article
- Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.The review of diabetic studies : RDS · 2021Article
- The association between plasma homocysteine level and metabolic syndrome. A record-based study of Saudi patients attending King Abdulaziz Medical City in Riyadh, Saudi Arabia.Saudi medical journal · 2020Article
- Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin-induced diabetic rats.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. Furthermore, it is strongly associated with other metabolic syndrome variables, such as hypertension, which is correlated with type II diabetes mellitus (T2DM). Studies on T2DM in relation to Hc levels have shown both positive and negative associations. The aim of the present study is to examine the relationship between Hc levels and risk of T2DM in the Lebanese population.
methodsWe sought to identify whether Hc associates positively or negatively with diabetes in a case-control study, where 2755 subjects enrolled from patients who had been catheterized for coronary artery diagnosis and treatment. We further sought to identify whether the gene variant MTHFR 667C>T is associated with T2DM, and how Hc and MTHFR 667C>T also impact other correlates of T2DM, including the widely used diuretics in this study population.
resultsWe found that Hc levels were significantly reduced among subjects with diabetes compared to those without diabetes when adjusted for all potential confounders (OR 0.640; 95% CI [0.44-0.92];
conclusionThese results suggest population-specific variations among a range of mechanisms that modulate the association of Hc and T2DM, providing a probe for future studies.
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