ArticleBiotechnology for biofuels2017
Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date.
Article in Biotechnology for biofuels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Industrial applications of Phanerochaete chrysosporium lignin-degrading enzymes: current status, production challenges, and future directions.World journal of microbiology & biotechnology · 2025Review
- Structure-function characterization of two enzymes from novel subfamilies of manganese peroxidases secreted by the lignocellulose-degrading Agaricales fungi Agrocybe pediades and Cyathus striatus.Biotechnology for biofuels and bioproducts · 2024Article
- Exoproteomic Study and Transcriptional Responses of Laccase and Ligninolytic Peroxidase Genes of White-Rot FungusInternational journal of molecular sciences · 2023Article
- Recent Theoretical Insights into the Oxidative Degradation of Biopolymers and Plastics by Metalloenzymes.International journal of molecular sciences · 2023Review
- Comparative analysis of simulatedFrontiers in microbiology · 2023Article
- Engineering functional thermostable proteins using ancestral sequence reconstruction.The Journal of biological chemistry · 2022Review
- Fungal Enzymes Involved in Plastics Biodegradation.Microorganisms · 2022Review
- Article
- Stable and Functionally Diverse Versatile Peroxidases Designed Directly from Sequences.Journal of the American Chemical Society · 2022Article
- Ancestral sequence reconstruction as a tool to study the evolution of wood decaying fungi.Frontiers in fungal biology · 2022Review
- Agaricales Mushroom Lignin Peroxidase: From Structure-Function to Degradative Capabilities.Antioxidants (Basel, Switzerland) · 2021Article
- Textile Dye Biodecolorization by Manganese Peroxidase: A Review.Molecules (Basel, Switzerland) · 2021Review
- Mutational and structural analysis of an ancestral fungal dye-decolorizing peroxidase.The FEBS journal · 2021Article
- Genomic Analysis Enlightens Agaricales Lifestyle Evolution and Increasing Peroxidase Diversity.Molecular biology and evolution · 2021Article
- Comparing Ligninolytic Capabilities of Bacterial and Fungal Dye-Decolorizing Peroxidases and Class-II Peroxidase-Catalases.International journal of molecular sciences · 2021Article
- Ancestral Resurrection and Directed Evolution of Fungal Mesozoic Laccases.Applied and environmental microbiology · 2020Article
- In silico definition of new ligninolytic peroxidase sub-classes in fungi and putative relation to fungal life style.Scientific reports · 2019Article
- Peroxidase evolution in white-rot fungi follows wood lignin evolution in plants.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Increase of Redox Potential during the Evolution of Enzymes Degrading Recalcitrant Lignin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Binding and Catalytic Mechanisms of Veratryl Alcohol Oxidation by Lignin Peroxidase: A Theoretical and Experimental Study.Computational and structural biotechnology journal · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFloudas et al. (
resultsWith this purpose, we analyzed the evolutionary pathway leading to the most efficient lignin-degrading peroxidases characterizing Polyporales species. After sequence reconstruction from 113 genes of ten sequenced genomes, the main enzyme intermediates were resurrected and characterized. Biochemical changes were analyzed together with predicted sequences and structures, to understand how these enzymes acquired the ability to degrade lignin and how this ability changed with time. The most probable first peroxidase in Polyporales would be a manganese peroxidase (Mn
conclusionsWe show how the change in peroxidase catalytic activities meant an evolutionary exploration for more efficient ways of lignin degradation by fungi, a key step for carbon recycling in land ecosystems. The study provides ancestral enzymes with a potential biotechnological interest for the sustainable production of fuels and chemicals in a biomass-based economy.
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