Evidence map›Paper›PMID 28331527›Full record

ArticleAIDS research and therapy2017

Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia.

Berhe Beyene Gebrezgabher, Yigzaw Kebede, Melaku Kindie, Desalegn Tetemke, Mebrahtu Abay, Yalemzewod Assefa Gelaw

Abstract read
In one paragraph

Article in AIDS research and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Berhe Beyene GebrezgabherDepartment of Public Health, Health Science College, Axum University, Axum, Ethiopia.
Yigzaw Kebede0000 0000 8539 4635grid.59547.3aDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, 196 Gondar, Ethiopia.
Melaku Kindie0000 0000 8539 4635grid.59547.3aDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, 196 Gondar, Ethiopia.
Desalegn TetemkeDepartment of Public Health, Health Science College, Axum University, Axum, Ethiopia.
Mebrahtu AbayDepartment of Public Health, Health Science College, Axum University, Axum, Ethiopia.
Yalemzewod Assefa Gelaw0000 0000 8539 4635grid.59547.3aDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, 196 Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people's living human immunodeficiency virus. Though manifold factors have reported as determinant factors of antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of patients in the study setting.

methodsAn institution based unmatched case-control study was conducted in Aksum town. Individuals who had a 6-month follow-up with complete individual information were included in the study. Document review and interviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the determinant factors of non-adherence.

resultsA total of 411 (137 cases and 274 control) study participants were included in the study. The majority of them were male in sex. Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse effect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95% CI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm

conclusionProgram, social and individual related factors showed a statistically significant associated with non-adherence to antiretroviral therapy. Managing lifestyle by developing self-efficacy of individuals and treating related threat to improve adherence status of antiretroviral therapy is recommended in this study.

Indexed as

Medication AdherenceAdolescentAdultAgedAged, 80 and overAnti-HIV AgentsCase-Control StudiesEthiopiaFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedYoung AdultAnti-HIV AgentsAntiretroviral therapyCase–control studyNon-adherenceNorthern Ethiopia

Identifiers

PMID28331527
PMCPMC5359813

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.