Evidence map›Paper›PMID 28331244›Full record

ArticleMediators of inflammation2017

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte.

Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Letizia MezzasomaDepartment of Experimental Medicine, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.ORCID 0000-0002-6159-0927
Cinzia AntognelliDepartment of Experimental Medicine, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
Vincenzo Nicola TalesaDepartment of Experimental Medicine, University of Perugia, Piazzale L. Severi 1, 06129 Perugia, Italy.
University of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-1

Indexed as

Carrier ProteinsCaspase 1Cell SurvivalDown-RegulationEnzyme ActivationHomeostasisHumansInflammasomesInflammationInterleukin-1betaMacrophagesMAP Kinase Signaling SystemMonocytesNatriuretic Peptide, BrainNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinCarrier ProteinsCaspase 1InflammasomesInterleukin-1betaNatriuretic Peptide, BrainNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, human

Identifiers

PMID28331244
PMCPMC5346358
OpenAlexW2590902226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.