ArticleScientific reports2017
Transcription factors of Schizophyllum commune involved in mushroom formation and modulation of vegetative growth.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
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- Emerging roles of protein modifications in sexual reproduction and pathogenesis of filamentous fungi.Frontiers in microbiology · 2026Review
- Transcriptome Analysis and Its Application in Screening Genes Related to the Growth and Development ofJournal of fungi (Basel, Switzerland) · 2025Article
- Exploring the Critical Environmental Optima and Biotechnological Prospects of Fungal Fruiting Bodies.Microbial biotechnology · 2025Review
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Evidence for the Existence of Mating Subtypes Within theJournal of fungi (Basel, Switzerland) · 2025Article
- Orthrus: a Pumilio-family gene involved in fruiting body and dark stipe development inFrontiers in fungal biology · 2025Article
- Identification of Homeobox Transcription Factors in a Dimorphic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Current Advances in the Functional Genes of Edible and Medicinal Fungi: Research Techniques, Functional Analysis, and Prospects.Journal of fungi (Basel, Switzerland) · 2024Review
- Regulatory functions of homeobox domain transcription factors in fungi.Applied and environmental microbiology · 2024Review
- Snowball: a novel gene family required for developmental patterning of fruiting bodies of mushroom-forming fungi (Agaricomycetes).mSystems · 2024Article
- "You Are What You Eat": How Fungal Adaptation Can Be Leveraged toward Myco-Material Properties.Global challenges (Hoboken, NJ) · 2024Article
- Cloning and Expression Analysis of Bioluminescence Genes inMycobiology · 2024Article
- Integration of Metabolomes and Transcriptomes Provides Insights into Morphogenesis and Maturation inJournal of fungi (Basel, Switzerland) · 2023Article
- Transcription factors: switches for regulating growth and development in macrofungi.Applied microbiology and biotechnology · 2023Review
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability.Materials today. Bio · 2023Article
- Hydrophobin GeneInternational journal of molecular sciences · 2023Article
- The transcription factor Ste12-like increases the mycelial abiotic stress tolerance and regulates the fruiting body development ofFrontiers in microbiology · 2023Article
- Transcriptome Profiling Reveals Candidate Genes Related to Stipe Gradient Elongation ofJournal of fungi (Basel, Switzerland) · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mushrooms are the most conspicuous fungal structures. Transcription factors (TFs) Bri1 and Hom1 of the model fungus Schizophyllum commune are involved in late stages of mushroom development, while Wc-2, Hom2, and Fst4 function early in development. Here, it is shown that Bri1 and Hom1 also stimulate vegetative growth, while biomass formation is repressed by Wc-2, Hom2, and Fst4. The Δbri1Δbri1 and the Δhom1Δhom1 strains formed up to 0.6 fold less biomass when compared to wild-type, while Δwc-2Δwc-2, Δhom2Δhom2, and Δfst4Δfst4 strains formed up to 2.8 fold more biomass. Inactivation of TF gene tea1, which was downregulated in the Δwc-2Δwc-2, Δhom2Δhom2, and Δfst4Δfst4 strains, resulted in a strain that was severely affected in mushroom development and that produced 1.3 fold more biomass than the wild-type. In contrast, introducing a constitutive active version of hom2 that had 4 predicted phosphorylation motifs eliminated resulted in radial growth inhibition and prompt fructification in both Δhom2 and wild-type strains, even in sterile monokaryons. Together, it is concluded that TFs involved in mushroom formation also modulate vegetative growth. Among these TFs is the homeodomain protein Hom2, being the first time that this class of regulatory proteins is implicated in repression of vegetative growth in a eukaryote.
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