Evidence map›Paper›PMID 28331185›Full record

ArticleScientific reports2017

The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling.

Daria V Ilatovskaya, Oleg Palygin, Vladislav Levchenko, Bradley T Endres, Alexander Staruschenko

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Article
  3. Blood Pressure Management Strategies and Podocyte Health.American journal of hypertension · 2025
    Review
  4. Article
  5. Renin-angiotensin system-mediated nitric oxide signaling in podocytes.American journal of physiology. Renal physiology · 2024
    Article
  6. Article
  7. Article
  8. Store-operated CaAmerican journal of physiology. Renal physiology · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Clemizole and LaPhysiological reports · 2021
    Article
  13. Cytoskeleton Rearrangements Modulate TRPC6 Channel Activity in Podocytes.International journal of molecular sciences · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. NADPH Oxidase Inhibition in Fibrotic Pathologies.Antioxidants & redox signaling · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daria V IlatovskayaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.ORCID 0000-0002-3680-5527
Vladislav LevchenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.
Bradley T EndresDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA. staruschenko@mcw.edu.ORCID 0000-0002-5190-8356
Medical College of Wisconsin · US

Funding

Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Mechanisms and relevance of ENaC regulation by EGF and Rac1R01HL108880 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI STARUSCHENKO, ALEXANDER · 2012 to 2016
$1.9M
Role of NOX4 In Kidney Function In Salt-Sensitive HypertensionR01HL122662 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W, STARUSCHENKO, ALEXANDER · 2015 to 2018
$1.5M
The involvement of ATP-dependent inhibition of ENaC in ARPKD cystogenesisR00DK105160 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ILATOVSKAYA, DARIA · 2018 to 2020
$747k
The involvement of ATP-dependent inhibition of ENaC in ARPKD cystogenesisK99DK105160 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI ILATOVSKAYA, DARIA · 2015 to 2016
$180k
American Heart Association-American Stroke Association 16EIA26720006NHLBI NIH HHS R01 HL108880NHLBI NIH HHS R01 HL122662NHLBI NIH HHS R35 HL135749NIDDK NIH HHS K99 DK105160NIDDK NIH HHS R00 DK105160
6 · The paper itself

Abstract

Podocytes are becoming a primary focus of research efforts due to their association with progressive glomeruli damage in disease states. Loss of podocytes can occur as a result of excessive intracellular calcium influx, and we have previously shown that angiotensin II (Ang II) via canonical transient receptor potential 6 (TRPC6) channels caused increased intracellular Ca

Indexed as

Angiotensin IIAnimalsCalciumImaging, Three-DimensionalKidney GlomerulusMicroscopy, ConfocalPatch-Clamp TechniquesPodocytesRatsTRPC6 Cation ChannelVasoconstrictor AgentsAngiotensin IICalciumTRPC6 Cation ChannelVasoconstrictor Agents

Identifiers

PMID28331185
PMCPMC5428415
OpenAlexW2689900182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.