ArticleScientific reports2017
Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- NaCl and urea modulate CD8+ T cell survival, renal accumulation, and response to BK virus.JCI insight · 2025Article
- The modulatory effect of high salt on immune cells and related diseases.Cell proliferation · 2022Review
- Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury.Journal of clinical medicine · 2021Review
- Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline.Investigative ophthalmology & visual science · 2021Article
- Review
- Kidney dendritic cells: fundamental biology and functional roles in health and disease.Nature reviews. Nephrology · 2020Review
- [About salt and immunity-a story of Mr. Hyde : The influence of hyperosmolar microenvironment on immune response].Der Pathologe · 2019Review
- HIF1A and NFAT5 coordinate NaAutophagy · 2019Article
- Interplay of NaFrontiers in immunology · 2019Review
- Regulation of Inflammatory Functions of Macrophages and T Lymphocytes by NFAT5.Frontiers in immunology · 2019Review
- Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.The American journal of pathology · 2018Article
- Salt, Hypertension, and Immunity.Annual review of physiology · 2018Review
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue osmolarity varies among different organs and can be considerably increased under pathologic conditions. Hyperosmolarity has been associated with altered stimulatory properties of immune cells, especially macrophages and dendritic cells. We have recently reported that dendritic cells upon exposure to hypertonic stimuli shift their profile towards a macrophage-M2-like phenotype, resulting in attenuated local alloreactivity during acute kidney graft rejection. Here, we examined how hyperosmotic microenvironment affects the cross-priming capacity of dendritic cells. Using ovalbumin as model antigen, we showed that exposure of dendritic cells to hyperosmolarity strongly inhibits activation of antigen-specific T cells despite enhancement of antigen uptake, processing and presentation. We identified TRIF as key mediator of this phenomenon. Moreover, we detected a hyperosmolarity-triggered, TRIF-dependent clustering of MHCI loaded with the ovalbumin-derived epitope, but not of overall MHCI molecules, providing a possible explanation for a reduced T cell activation. Our findings identify dendritic cells as important players in hyperosmolarity-mediated immune imbalance and provide evidence for a novel pathway of inhibition of antigen specific CD8
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