Evidence map›Paper›PMID 28331174›Full record

ArticleScientific reports2017

Development of Customized [

Andrew V Mossine, Allen F Brooks, Naoko Ichiishi, Katarina J Makaravage, Melanie S Sanford, Peter J H Scott

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 86 citations in OpenAlex.

  1. Recent advances in [Nuclear medicine and biology · 2026
    Review
  2. Article
  3. Article
  4. A simplified, robust protocol for [Scientific reports · 2025
    Article
  5. Article
  6. Article
  7. Improved Radiosynthesis of [ACS infectious diseases · 2025
    Article
  8. Review
  9. Article
  10. Triflyl [Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  11. Review
  12. Simple and Efficient Synthesis ofPharmaceuticals (Basel, Switzerland) · 2024
    Article
  13. One-Step Synthesis of [ACS central science · 2024
    Article
  14. Automation of Copper-MediatedMolecules (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Article
  17. Radiosynthesis and biological evaluation of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  18. Article
  19. [Molecules (Basel, Switzerland) · 2023
    Article
  20. One-Pot Radiosynthesis of [Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Andrew V MossineDepartment of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6289-196X
Allen F BrooksDepartment of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI, 48109, USA.
Naoko IchiishiDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI, 48109, USA.
Katarina J MakaravageDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI, 48109, USA.
Melanie S SanfordDepartment of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI, 48109, USA. mssanfor@umich.edu.
Peter J H ScottDepartment of Radiology, University of Michigan Medical School, 1301 Catherine St., Ann Arbor, MI, 48109, USA. pjhscott@umich.edu.
University of Michigan · US

Funding

Synthesis of Novel PET Radiotracers for Imaging in Alzheimer’s Disease and Related DisordersR01EB021155 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S., SCOTT, PETER JAMES HENRY · 2016 to 2024
$3.2M
NIBIB NIH HHS R01 EB021155
6 · The paper itself

Abstract

In a relatively short period of time, transition metal-mediated radiofluorination reactions have changed the PET radiochemistry landscape. These reactions have enabled the radiofluorination of a wide range of substrates, facilitating access to radiopharmaceuticals that were challenging to synthesize using traditional fluorine-18 radiochemistry. However, the process of adapting these new reactions for automated radiopharmaceutical production has revealed limitations in fitting them into the confines of traditional radiochemistry systems. In particular, the presence of bases (e.g. K

Indexed as

Chromatography, LiquidCopperFluorine RadioisotopesHumansPositron-Emission TomographyRadiopharmaceuticalsTrace ElementsCopperFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsTrace Elements

Identifiers

PMID28331174
PMCPMC5427906
OpenAlexW2595277727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.