Evidence map›Paper›PMID 28331094›Full record

ArticleJournal of virology2017

Herpes Simplex Virus gE/gI and US9 Promote both Envelopment and Sorting of Virus Particles in the Cytoplasm of Neurons, Two Processes That Precede Anterograde Transport in Axons.

Grayson DuRaine, Todd W Wisner, Paul Howard, Melissa Williams, David C Johnson

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. LIVE-CELL FLUORESCENCE MICROSCOPY OF HSV-1 CELLULAR EGRESS BY EXOCYTOSIS.bioRxiv : the preprint server for biology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Frontiers in microbiology · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV.Methods in molecular biology (Clifton, N.J.) · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. HSV-1 Cytoplasmic Envelopment and Egress.International journal of molecular sciences · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Grayson DuRaineDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Todd W WisnerDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Paul HowardDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Melissa WilliamsMultiscale Microscopy Core, Oregon Health & Science University, Portland, Oregon, USA.
David C JohnsonDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA johnsoda@ohsu.edu.
Oregon Health & Science University · US

Funding

Herpes simplex virus egress from neurons into axons mediated by HSV membrane proteins gE/gI and US9 and axonal transport by kinesin motors.R01EY018755 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSON, DAVID C. · 2008 to 2023
$5.8M
NEI NIH HHS R01 EY018755
6 · The paper itself

Abstract

Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowing spread from latently infected ganglia to epithelial tissues, where viral progeny are produced in numbers allowing spread to other hosts. The HSV membrane proteins gE/gI and US9 initiate the process of anterograde axonal transport, ensuring that virus particles are transported from the cytoplasm into the most proximal segments of axons. These proteins do not appear to be important once HSV is inside axons. We previously described HSV double mutants lacking both gE and US9 that failed to transport virus particles into axons. Here we show that gE

Indexed as

AnimalsAxonal TransportAxonsCapsidCell LineChlorocebus aethiopsCytoplasmIntracellular Signaling Peptides and ProteinsKinesinsLipoproteinsMutationNeuronsPhosphoproteinsProtein TransportSimplexvirusVero CellsIntracellular Signaling Peptides and ProteinsKinesinsLipoproteinsPhosphoproteinsUS9 protein, Human herpesvirus 1Viral Envelope ProteinsViral Proteinsanterogradeaxonsenvelopmentglycoproteinskinesinsneuron

Identifiers

PMID28331094
PMCPMC5432863
OpenAlexW2599766400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.