ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03900832 (Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Repeated warm water baths decrease sympathetic activity in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Different Responses of Muscle Sympathetic Nerve Activity to Dapagliflozin Between Patients With Type 2 Diabetes With and Without Heart Failure.Journal of the American Heart Association · 2021Article
- Acute effects of sublingual nitroglycerin on cardiovagal and sympathetic baroreflex sensitivity.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Sympathetic activation due to limb venous distension is preserved during muscle metaboreceptor stimulation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Moderate whole body heating attenuates the exercise pressor reflex responses in older humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Lower-limb venous distension reflex and orthostatic tolerance in young healthy humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Habitual cigarette smoking raises pressor responses to spontaneous bursts of muscle sympathetic nerve activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults.The Journal of physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Heat stress evokes significant increases in muscle sympathetic nerve activity (MSNA) in healthy individuals. The MSNA response to heat stress in chronic heart failure (CHF) is unknown. We hypothesized that the MSNA response to heat stress is attenuated in CHF. Passive whole body heating was applied with water-perfused suits in 13 patients (61 ± 2 yr) with stable class II-III CHF, 12 age-matched (62 ± 2 yr) healthy subjects, and 14 young (24 ± 1 yr) healthy subjects. Mild heating (i.e., increases in skin temperature ΔTsk ~2-4°C, internal temperature ΔTcore <0.3°C) significantly decreased MSNA in CHF patients; however, it did not significantly alter the MSNA in the age-matched and young healthy subjects. Heat stress (i.e., ΔTsk ~4°C and ΔTcore ~0.6°C) raised MSNA in the age-matched (32.9 ± 3.2 to 45.6 ± 4.2 bursts/min;
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