ArticleThe Journal of biological chemistry2017
NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
55 citing papers in PubMed, 93 citations in OpenAlex.
- Bilirubin reduces mortality in sepsis models by inhibiting NOX2-mediated formation of neutrophil extracellular traps.Redox report : communications in free radical research · 2026Article
- NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine.Molecular psychiatry · 2026Article
- Iron Metabolism in the Colorectal Tumor Microenvironment: From Preneoplastic Lesions to Cancer Progression.International journal of molecular sciences · 2026Review
- Cytokines at the Crossroads of Mitochondrial Dysfunction and Inflammation in Colorectal Cancer: Implications for Postoperative Complications.Molecular diagnosis & therapy · 2026Review
- Scutellarin regulates MAPK/ERK signalling in nasopharyngeal cancer via the apoptotic and ROS induced DNA damage.Translational oncology · 2026Article
- Piperine Induces Apoptosis and Cell Cycle Arrest via Multiple Oxidative Stress Mechanisms and Regulation of PI3K/Akt and MAPK Signaling in Colorectal Cancer Cells.Antioxidants (Basel, Switzerland) · 2025Article
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- NOX Family: Regulators of Reactive Oxygen Species Balance in Tumor Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Review
- HIF-1α Mediated Regulation of Glioblastoma Malignant Phenotypes through CD47 Protein: Understanding Functions and Mechanisms.Journal of Cancer · 2025Article
- Targeting of the NOX1/ADAM17 Enzymatic Complex Regulates Soluble MCAM-Dependent Pro-Tumorigenic Activity in Colorectal Cancer.Biomedicines · 2023Article
- Analysis of the Prognostic Potential of Schlafen 11, Programmed Death Ligand 1, and Redox Status in Colorectal Cancer Patients.International journal of molecular sciences · 2023Article
- NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.Journal of medicinal chemistry · 2023Review
- NADPH oxidase 1: A target in the capacity of dimeric ECG and EGCG procyanidins to inhibit colorectal cancer cell invasion.Redox biology · 2023Article
- Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production.Cell biology and toxicology · 2023Article
- Cancer Metabolism: The Role of ROS in DNA Damage and Induction of Apoptosis in Cancer Cells.Metabolites · 2023Review
- Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure.Molecular biology reports · 2023Article
- Redox Properties, Bioactivity and Health Effects of Indicaxanthin, a Bioavailable Phytochemical fromAntioxidants (Basel, Switzerland) · 2022Review
- Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance.Biomolecules & therapeutics · 2022Review
- NOX as a Therapeutic Target in Liver Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Agnes JuhaszFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Susan Markelthe Department of Medical Oncology and Therapeutics Research and.
Shikha Gaurthe Department of Medical Oncology and Therapeutics Research and.
Han Liuthe Division of Cancer Treatment and Diagnosis, NCI, National Institutes of Health, Bethesda, Maryland 20892.
Jiamo LuFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Guojian JiangFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Xiwei Wuthe Bioinformatics Group, City of Hope Comprehensive Cancer Center, Duarte, California 91010.
Smitha AntonyFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Yongzhong WuFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Giovanni Melillothe Developmental Therapeutics Program, SAIC-Frederick, Inc., NCI at Frederick, Frederick, Maryland 21702, and.
Jennifer L MeitzlerFrom the Developmental Therapeutics Branch of the Center for Cancer Research.
Diana C Hainesthe Pathology/Histotechnology Laboratory, Leidos, Inc./Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland 21702.
Donna Butcherthe Pathology/Histotechnology Laboratory, Leidos, Inc./Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland 21702.
Krishnendu Roythe Division of Cancer Treatment and Diagnosis, NCI, National Institutes of Health, Bethesda, Maryland 20892.
James H DoroshowFrom the Developmental Therapeutics Branch of the Center for Cancer Research, doroshoj@mail.NIH.gov.
Center for Cancer Research · USNational Institutes of Health · USCity of Hope · USFrederick National Laboratory for Cancer Research · USLeidos (United States) · USScience Applications International Corporation (United States) · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3MNADPH Oxidases as Novel Targets for Cancer TherapyZIABC010677 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES · 2009 to 2025
$15.1MNADPH Oxidase 1: A Novel Target for Colon Cancer TherapyZ01BC010677 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DOROSHOW, JAMES HALPERN · 2005 to 2008
$1.1MIntramural NIH HHS Z01 BC010677NCI NIH HHS P30 CA033572
Abstract
Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation. NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates O
Indexed as
Gene Expression Regulation, NeoplasticMAP Kinase Signaling SystemAnimalsApoptosisCell CycleCell Line, TumorCell ProliferationColonColonic NeoplasmsCyclin D1HT29 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceNADPH Oxidase 1CCND1 protein, humanCyclin D1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNADPH Oxidase 1NADPH OxidasesNOX1 protein, humanPlatelet Endothelial Cell Adhesion Molecule-1Reactive Oxygen SpeciesRNA, Small InterferingVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesiscell cyclecolon cancercyclin D1mitogen-activated protein kinase (MAPK)NADPH oxidaseprotein phosphatasereactive oxygen species (ROS)
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.