Evidence map›Paper›PMID 28330868›Full record

ArticleThe Journal of biological chemistry2017

Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor γ-dependent macrophage differentiation.

Irina Tikhanovich, Jie Zhao, Jody Olson, Abby Adams, Ryan Taylor, Brian Bridges, Laurie Marshall, Benjamin Roberts, Steven A Weinman

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  16. The Role of Protein Methyltransferases in Immunity.Molecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Irina TikhanovichFrom the Department of Internal Medicine and.
Jie ZhaoFrom the Department of Internal Medicine and.
Jody OlsonFrom the Department of Internal Medicine and.
Abby AdamsFrom the Department of Internal Medicine and.
Ryan TaylorFrom the Department of Internal Medicine and.
Brian Bridgesthe Liver Center, University of Kansas Medical Center, Kansas City, Kansas 66160.
Laurie Marshallthe Liver Center, University of Kansas Medical Center, Kansas City, Kansas 66160.
Benjamin Robertsthe Liver Center, University of Kansas Medical Center, Kansas City, Kansas 66160.
Steven A WeinmanFrom the Department of Internal Medicine and sweinman@kumc.edu.
University of Kansas Medical Center · US

Funding

THE ROLE OF HUMAN PXR IN ANTI-TUBERCULOSIS DRUG-INDUCED LIVER INJURYP20RR021940 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI COPPLE, BRYAN L · 2006 to 2011
$12.1M
Role of alcohol adapted Kupffer cells in the progression and resolution of ALDR01AA012863 · NIAAA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI STEVEN A WEINMAN · 2000 to 2026
$10.2M
Nuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1M
NCRR NIH HHS P20 RR021940NIAAA NIH HHS R01 AA012863NIGMS NIH HHS P20 GM103549
6 · The paper itself

Abstract

Arginine methylation is a common posttranslational modification that has been shown to regulate both gene expression and extranuclear signaling events. We recently reported defects in protein arginine methyltransferase 1 (PRMT1) activity and arginine methylation in the livers of cirrhosis patients with a history of recurrent infections. To examine the role of PRMT1 in innate immune responses

Indexed as

Immunity, InnateAnimalsAntibodiesArginineCell DifferentiationCytokinesFemaleHistonesHumansInterleukin-4LipopolysaccharidesLiver CirrhosisMacrophagesMacrophages, PeritonealMaleMethylationAntibodiesArginineCytokinesHistonesInterleukin-4LipopolysaccharidesPPAR gammaPRMT1 protein, humanPrmt1 protein, mouseProtein-Arginine N-MethyltransferasesRepressor Proteinsarginine methylationcecal ligation and puncturedifferentiationhistone arginine methylationinnate immunitymacrophagemonocytesepsis

Identifiers

PMID28330868
PMCPMC5409459
OpenAlexW2598621195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.