ArticleCell systems2017
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule.
Article in Cell systems, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 90 citations in OpenAlex.
- LYNX: a deep generative model for linking spatial dynamics and cell interactions in multimodal spatial data.bioRxiv : the preprint server for biology · 2026Article
- Non-invasive Assessment of Pancreatic Duct Hypertension Using Computational Flow Modeling.Annals of biomedical engineering · 2026Article
- 3D reconstruction of human liver tissue at cellular resolution.Science advances · 2026Article
- Bile canaliculi formation in primary hepatocytes requires α1β1 integrin-dependent adherens junction re-organization.Journal of cell science · 2025Article
- Article
- Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas.Scientific reports · 2024Article
- Review on bile dynamics and microfluidic-based component detection: Advancing the understanding of bilestone pathogenesis in the biliary tract.Biomicrofluidics · 2024Article
- Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease.EMBO reports · 2023Article
- Validation of AI-based software for objectification of conjunctival provocation test.The journal of allergy and clinical immunology. Global · 2023Article
- A modular analysis of bile canalicular function and its implications for cholestasis.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure.The Journal of cell biology · 2023Article
- Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy.iScience · 2023Article
- Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022Article
- From Seeing to Simulating: A Survey of Imaging Techniques and Spatially-Resolved Data for Developing Multiscale Computational Models of Liver Regeneration.Frontiers in systems biology · 2022Article
- Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.The Journal of cell biology · 2021Article
- Spatial architecture of biliary tree in mammals: Fractal and Euclidean geometric features.Journal of anatomy · 2021Article
- Modeling alcohol-associated liver disease in a human Liver-Chip.Cell reports · 2021Article
- High-resolution three-dimensional visualization of hepatic sinusoids in cirrhotic rats via serial histological sections.Histology and histopathology · 2021Article
- Intravital Microscopy for the Study of Hepatic Glucose Uptake.Current protocols · 2021Article
- Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 4 countries.
Funding
Abstract
Bile, the central metabolic product of the liver, is transported by the bile canaliculi network. The impairment of bile flow in cholestatic liver diseases has urged a demand for insights into its regulation. Here, we developed a predictive 3D multi-scale model that simulates fluid dynamic properties successively from the subcellular to the tissue level. The model integrates the structure of the bile canalicular network in the mouse liver lobule, as determined by high-resolution confocal and serial block-face scanning electron microscopy, with measurements of bile transport by intravital microscopy. The combined experiment-theory approach revealed spatial heterogeneities of biliary geometry and hepatocyte transport activity. Based on this, our model predicts gradients of bile velocity and pressure in the liver lobule. Validation of the model predictions by pharmacological inhibition of Rho kinase demonstrated a requirement of canaliculi contractility for bile flow in vivo. Our model can be applied to functionally characterize liver diseases and quantitatively estimate biliary transport upon drug-induced liver injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.