Evidence map›Paper›PMID 28330501›Full record

ArticleStem cell research & therapy2017

Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function.

Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra, Timothy Q Duong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lei HuangResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
Yichu LiuDepartment of Biomedical Engineering, University of Texas, San Antonio, Texas, USA.
Jianfei LuResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
Bianca CerqueiraResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
Vivek MisraDepartment of Neurology, University of Texas Health Science Center, San Antonio, Texas, USA.
Timothy Q DuongResearch Imaging Institute, University of Texas Health Science Center, San Antonio, Texas, USA. tim.duong@stonybrookmedicine.edu.
The University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · US

Funding

Stroke Imaging of Conscious RatsR01NS045879 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DUONG, TIMOTHY Q. · 2004 to 2014
$3.1M
NINDS NIH HHS R01 NS045879
6 · The paper itself

Abstract

backgroundHuman umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not well understood. This study evaluated the effects of hyperacute intraarterial transplantation of hUCB mononuclear cells (MNCs) on cerebrovascular function in stroke rats using serial magnetic resonance imaging (MRI).

methodsHUCB MNCs or vehicle were administered to stroke rats via the internal carotid artery immediately after reperfusion at 60 min following ischemia onset. Lesion volumes were longitudinally evaluated by MRI on days 0, 2, 14, and 28 after stroke, accompanied by behavioral tests. Cerebral blood flow (CBF) and cerebrovascular reactivity were measured by perfusion MRI and CO

resultsWe found that CBF to the stroke-affected region at 28 days was improved (normalized CBF value: 1.41 ± 0.30 versus 0.49 ± 0.07) by intraarterial transplantation of hUCB MNCs in the hyperacute stroke phase, compared to vehicle control. Cerebrovascular reactivity within the stroke-affected area, measured by CBF fMRI, was also increased (35.2 ± 3.5% versus 12.8 ± 4.3%), as well as the corresponding cerebrovascular density. Some engrafted cells appeared with microvascular-like morphology and stained positive for von Willebrand Factor (an endothelial cell marker), suggesting they differentiated into endothelial cells. Some engrafted cells also connected to host endothelial cells, suggesting they interacted with the host vasculature. Compared to the vehicle group, infarct volume at 28 days in the stem cell treated group was significantly smaller (160.9 ± 15.7 versus 231.2 ± 16.0 mm

conclusionsIntraarterial hUCB MNC transplantation during the hyperacute phase of ischemic stroke improved cerebrovascular function and reduced behavioral deficits and infarct volume.

Indexed as

AnimalsBiomarkersBlood Flow VelocityBrain IschemiaCarotid Artery, InternalCell DifferentiationCell SeparationCerebrovascular CirculationDisease Models, AnimalEndothelial CellsFetal BloodGene ExpressionHumansInjections, Intra-ArterialLeukocytes, MononuclearMaleBiomarkersvon Willebrand FactorCBFCell transplantationMRIStrokeUmbilical cord blood cellVasoreactivity

Identifiers

PMID28330501
PMCPMC5361847
OpenAlexW2598834666

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.