Evidence map›Paper›PMID 28330496›Full record

ArticleActa neuropathologica communications2017

Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis.

David R Amici, Iago Pinal-Fernandez, Davi A G Mázala, Thomas E Lloyd, Andrea M Corse, Lisa Christopher-Stine, Andrew L Mammen, Eva R Chin

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 60 citations in OpenAlex.

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  4. The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026
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  10. Skeletal muscle disorders as risk factors for type 2 diabetes.Molecular and cellular endocrinology · 2025
    Review
  11. Article
  12. Review
  13. The emerging roles of necroptosis in skeletal muscle health and disease.Pflugers Archiv : European journal of physiology · 2024
    Review
  14. Current biomarkers in inclusion body myositis.Journal of neuromuscular diseases · 2024
    Review
  15. Pathological autoantibody internalisation in myositis.Annals of the rheumatic diseases · 2024
    Article
  16. Article
  17. Cyclin-dependent kinase 5 (CDK5) inhibitors in Parkinson disease.Journal of cellular and molecular medicine · 2024
    Review
  18. Pathogenic autoantibody internalization in myositis.medRxiv : the preprint server for health sciences · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David R AmiciDepartment of Kinesiology, University of Maryland College Park, College Park, MD, USA.
Iago Pinal-FernandezMuscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
Davi A G MázalaDepartment of Kinesiology, University of Maryland College Park, College Park, MD, USA.
Thomas E LloydDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrea M CorseDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lisa Christopher-StineDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew L MammenMuscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA. andrew.mammen@nih.gov.
Eva R ChinDepartment of Kinesiology, University of Maryland College Park, College Park, MD, USA. erchin@umd.edu.
Johns Hopkins Medicine · USUniversity of Maryland, College Park · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · US

Funding

Muscle Disease UnitZIAAR041203 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI MAMMEN, ANDREW · 2015 to 2025
$19.7M
Nucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4M
Dynactin function in axons, synapses, and neurodegenerative diseaseR01NS082563 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E. · 2013 to 2017
$1.8M
NINDS NIH HHS R01 NS082563NINDS NIH HHS R01 NS094239
6 · The paper itself

Abstract

Sporadic inclusion body myositis (IBM) is the most common primary myopathy in the elderly, but its pathoetiology is still unclear. Perturbed myocellular calcium (Ca

Indexed as

AdultAgedCalciumCalpainEndoplasmic Reticulum StressFemaleHumansMaleMiddle AgedMuscle ProteinsMyositis, Inclusion BodyProtein BiosynthesisRNA, MessengerTranscriptomeUnfolded Protein ResponseCalciumCalpainCAPN1 protein, humanCAPN3 protein, humanMuscle ProteinsRNA, MessengerCalciumCalpainInclusion bodyMuscular diseasesMyositisUnfolded protein response

Identifiers

PMID28330496
PMCPMC5363023
OpenAlexW2601406675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.