ArticleCritical care (London, England)2017
Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study.
Article in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for Neuroprognostication in Critically Ill Adults with Status Epilepticus.Neurocritical care · 2026Guideline
- Incidence, mortality, and management of status epilepticus from 2012 to 2022: An 11-year nationwide study.Epilepsia · 2026Article
- Evaluation and comparison of mortality scores in status epilepticus patients.BMC neurology · 2025Article
- Trajectories of long-term survival after status epilepticus.Epilepsia · 2025Article
- Medications used for seizure-emergency management in the UK community: A clinical practice research datalink retrospective database study.Epilepsia open · 2025Article
- Cerebrospinal fluid and serum cytokine profiles in severe viral encephalitis with implications for refractory status epilepticus: a retrospective observational study.Frontiers in immunology · 2025Observational
- Postictal Encephalopathy After Status Epilepticus: Outcome and Risk Factors.Neurocritical care · 2024Article
- Outcomes and Treatment Approaches for Super-Refractory Status Epilepticus: A Systematic Review and Meta-Analysis.JAMA neurology · 2023Article
- Specific profiles of new-onset vs. non-inaugural status epilepticus: From diagnosis to 1-year outcome.Frontiers in neurology · 2023Article
- Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.Annals of the New York Academy of Sciences · 2020Article
- [Management of refractory and super-refractory status epilepticus].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2019Review
- fNIRS improves seizure detection in multimodal EEG-fNIRS recordings.Journal of biomedical optics · 2019Article
- Long-term outcomes of status epilepticus: A critical assessment.Epilepsia · 2018Article
- Updates in Refractory Status Epilepticus.Critical care research and practice · 2018Review
- Bringing EEG Back to the Future: Use of cEEG in Neurocritical Care.Epilepsy currentsArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study.
methodsThis was a retrospective study of the Finnish Intensive Care Consortium (FICC) database of adult patients (16 years of age or older) with ICU-treated RSE in Finland during a 3-year period (2010-2012). The database consists of admissions to all 20 Finnish hospitals treating RSE in the ICU. All five university hospitals and 11 out of 15 central hospitals participated in the present study. The total adult referral population in the study hospitals was 3.92 million, representing 91% of the adult population of Finland. Patients whose condition had a post-anoxic aetiological basis were excluded.
resultsWe identified 395 patients with ICU-treated RSE, corresponding to an annual incidence of 3.4/100,000 (95% confidence interval (CI) 3.04-3.71). Hospital mortality was 7.4% (95% CI 0-16.9%), and 1-year mortality was 25.4% (95% CI 21.2-29.8%). Mortality at hospital discharge was associated with severity of organ dysfunction. Mortality at 1 year was associated with older age (adjusted odds ratio (aOR) 1.033, 95% CI 1.104-1.051, p = 0.001), sequential organ failure assessment (SOFA) score (aOR 1.156, CI 1.051-1.271, p = 0.003), super-refractory status epilepticus (SRSE) (aOR 2.215, 95% CI 1.20-3.84, p = 0.010) and dependence in activities of daily living (ADL) (aOR 2.553, 95% CI 1.537-4.243, p < 0.0001).
conclusionsDespite low hospital mortality, 25% of ICU-treated RSE patients die within a year. Super-refractoriness, dependence in ADL functions, severity of organ dysfunction at ICU admission and older age predict long-term mortality.
trial registrationRetrospective registry study; no interventions on human participants.
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