ArticleBMC evolutionary biology2017
Discovery and evolution of novel hemerythrin genes in annelid worms.
Article in BMC evolutionary biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Diverse bacteriohemerythrin genes ofmBio · 2025Article
- Article
- Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens.Microorganisms · 2025Review
- Oxygen-binding proteins aid oxygen diffusion to enhance fitness of a yeast model of multicellularity.PLoS biology · 2025Article
- Examining the role of oxygen-binding proteins on the early evolution of multicellularity.bioRxiv : the preprint server for biology · 2023Article
- Genomic Analysis of a Scale Worm Provides Insights into Its Adaptation to Deep-Sea Hydrothermal Vents.Genome biology and evolution · 2023Article
- Evolutionary History of the Globin Gene Family in Annelids.Genome biology and evolution · 2020Article
- Newly Discovered Occurrences and Gene Tree of the Extracellular Globins and Linker Chains from the Giant Hexagonal Bilayer Hemoglobin in Metazoans.Genome biology and evolution · 2019Article
- Article
- Gene refashioning through innovative shifting of reading frames in mosses.Nature communications · 2018Article
- Broad Phylogenetic Occurrence of the Oxygen-Binding Hemerythrins in Bilaterians.Genome biology and evolution · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite extensive study on hemoglobins and hemocyanins, little is known about hemerythrin (Hr) evolutionary history. Four subgroups of Hrs have been documented, including: circulating Hr (cHr), myohemerythrin (myoHr), ovohemerythrin (ovoHr), and neurohemerythrin (nHr). Annelids have the greatest diversity of oxygen carrying proteins among animals and are the only phylum in which all Hr subgroups have been documented. To examine Hr diversity in annelids and to further understand evolution of Hrs, we employed approaches to survey annelid transcriptomes in silico.
resultsSequences of 214 putative Hr genes were identified from 44 annelid species in 40 different families and Bayesian inference revealed two major clades with strong statistical support. Notably, the topology of the Hr gene tree did not mirror the phylogeny of Annelida as presently understood, and we found evidence of extensive Hr gene duplication and loss in annelids. Gene tree topology supported monophyly of cHrs and a myoHr clade that included nHrs sequences, indicating these designations are functional rather than evolutionary.
conclusionsThe presence of several cHrs in early branching taxa suggests that a variety of Hrs were present in the common ancestor of extant annelids. Although our analysis was limited to expressed-coding regions, our findings demonstrate a greater diversity of Hrs among annelids than previously reported.
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