Article3 Biotech2016
Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes.
Article in 3 Biotech, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- In vivo biological screening of extract and bioactive compound from Ficus benghalensis L. and their in silico molecular docking analysis.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
- Review
- In Vivo and In Vitro Biological Evaluation and Molecular Docking Studies of Compounds Isolated fromMolecules (Basel, Switzerland) · 2022Article
- Genus Ziziphus for the treatment of chronic inflammatory diseases.Saudi journal of biological sciences · 2021Review
- The analgesic potential of glycosides derived from medicinal plants.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Review
- Investigation the effect of jujube seed capsule on sleep quality of postmenopausal women: A double-blind randomized clinical trial.BioMedicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ziziphus nummularia from Rhamnaceae family is traditionally used for sedative-hypnotic, antipyretic and analgesic purposes; however, scientific validations are lacking. This in vivo study was undertaken to verify the above ameliorative properties of Z. nummularia root methanolic extract. Various fractions of the extract were assayed on Balb/c mice by open field, Brewer's yeast-induced hyperthermia and acetic acid-induced writhing experiments. The significance of the outcomes was analyzed with statistical tests. Various fractions of the extract exhibited marked dose-dependent (p < 0.05) sedative-hypnotic and antipyretic activities. The biological efficacies were most pronounced between 50 and 100 mg/kg. Further, the acetic acid-induced abdominal constrictions were significantly (p < 0.05) attenuated by the extract. Chloroform fraction of the extract was most dominant followed by ethyl acetate. The demonstrated therapeutic attributes of Z. nummularia extract can be exploited to isolate pharmaceutically relevant compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.