ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2019
Neighborhood Disadvantage and Biological Aging: Using Marginal Structural Models to Assess the Link Between Neighborhood Census Variables and Epigenetic Aging.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- Structural and social determinants of health shape the impact of neurodegeneration and cerebrovascular pathology on cognitive functioning in black adults.Social science & medicine (1982) · 2026Article
- Neighborhood disadvantage and accelerated epigenetic aging in the early aftermath of trauma: The moderating role of individual psychological resources.Journal of psychiatric research · 2026Article
- Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing.Frontiers in aging neuroscience · 2026Review
- Living in historically redlined neighborhoods and biological aging among older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Accelerated molecular aging in socioeconomically disadvantaged neighborhoods: A racial/ethnic comparison.Health & place · 2025Article
- Methylation and algorithms in biological aging: a scoping review.Frontiers in aging · 2025Review
- Neighborhood Stressors and Epigenetic Age Acceleration Among Older Americans.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Assessment of disparities in timely diagnosis and comprehensive workup of cognitive impairment between English and Spanish speakers.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Neighborhood Disadvantage and Parenting in Early Adolescence Predict Epigenetic Aging and Mortality Risk in Adulthood.Journal of youth and adolescence · 2024Article
- Neighborhood Environment and Epigenetic Age: A Scoping Review.Western journal of nursing research · 2023Article
- Racial and Ethnic Residential Segregation and Monocyte DNA Methylation Age Acceleration.JAMA network open · 2023Article
- Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain.Social science & medicine (1982) · 2023Article
- Spatializing stigma-power: Mental health impacts of spatial stigma in a legally-excluded settlement in Mumbai, India.PLOS global public health · 2023Article
- Do Loneliness and Per Capita Income Combine to Increase the Pace of Biological Aging for Black Adults across Late Middle Age?International journal of environmental research and public health · 2022Article
- Methylation of FKBP5 is associated with accelerated DNA methylation ageing and cardiometabolic risk: replication in young-adult and middle-aged Black Americans.Epigenetics · 2022Article
- Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.International journal of epidemiology · 2022Article
- Childhood adversity predicts black young adults' DNA methylation-based accelerated aging: A dual pathway model.Development and psychopathology · 2022Article
- Understanding Health Inequalities Through the Lens of Social Epigenetics.Annual review of public health · 2022Review
- Radically reframing studies on neurobiology and socioeconomic circumstances: A call for social justice-oriented neuroscience.Frontiers in integrative neuroscience · 2022Article
Corrections and comments
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4 authors.
Funding
Abstract
objectivesPast research has reported an association between neighborhood disadvantage and healthy aging, but most of these studies utilize self-report measures of health or physical functioning and do not properly account for neighborhood selection effects, creating concerns regarding inflated associations. To overcome these limitations and provide a more stringent estimate of effects, the current study investigated the effect of neighborhood disadvantage on aging using newly developed epigenetic methods to assess rate of biological aging and marginal structural modeling (MSM) to account for potential confounds due to neighborhood selection.
methodsWe tested the hypothesis that neighborhood disadvantage accelerates aging using U.S. census data and five waves of interview data from a sample of 100 middle-aged African American women. Using a recently developed epigenetic index of aging, biological age was measured using weighted methylation values at 71 CpG sites. We calculated a measure of accelerated methylomic aging (in years) based upon the residual scores resulting from a regression of methylomic age on chronological age.
resultsControlling for a variety of individual difference factors that could be confounded with neighborhood effects, including various health behaviors, neighborhood disadvantage was associated with accelerated biological aging. Using MSM to account for selection effects, a standard deviation increase in neighborhood disadvantage accelerated aging an average of 9 months.
conclusionsOur findings converge with prior work to provide strong evidence that neighborhood context is a significant determinant of healthy aging.
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