Evidence map›Paper›PMID 28329718›Full record

ArticleDrug and alcohol dependence2017

A pilot investigation of acute inhibitory control training in cocaine users.

Joseph L Alcorn, Erika Pike, William S Stoops, Joshua A Lile, Craig R Rush

Abstract read
In one paragraph

Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph L AlcornDepartment of Behavioral Science, University of Kentucky College of Medicine, 1110 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington KY, 40536-0086, USA.
Erika PikeDepartment of Behavioral Science, University of Kentucky College of Medicine, 1110 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington KY, 40536-0086, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 110 Kastle Hall, Lexington, KY, 40506-0044, USA.
William S StoopsDepartment of Behavioral Science, University of Kentucky College of Medicine, 1110 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington KY, 40536-0086, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 110 Kastle Hall, Lexington, KY, 40506-0044, USA; Department of Psychiatry, University of Kentucky College of Medicine, 245 Fountain Court, Lexington, KY, 40509-1810, USA.
Joshua A LileDepartment of Behavioral Science, University of Kentucky College of Medicine, 1110 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington KY, 40536-0086, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 110 Kastle Hall, Lexington, KY, 40506-0044, USA; Department of Psychiatry, University of Kentucky College of Medicine, 245 Fountain Court, Lexington, KY, 40509-1810, USA.
Craig R RushDepartment of Behavioral Science, University of Kentucky College of Medicine, 1110 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington KY, 40536-0086, USA; Department of Psychology, University of Kentucky College of Arts and Sciences, 110 Kastle Hall, Lexington, KY, 40506-0044, USA; Department of Psychiatry, University of Kentucky College of Medicine, 245 Fountain Court, Lexington, KY, 40509-1810, USA. Electronic address: Craig.Rush@uky.edu.

Funding

Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Topiramate-Phentermine Combinations for Cocaine DependenceR01DA036827 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2014 to 2017
$1.9M
A Novel Anti Obesity Drug Combination as a Pharmacotherapy for Cocaine DependenceR01DA032254 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2012 to 2015
$1.9M
Medications Development for Cocaine: A Translational Approach in Monkey and HumanR01DA033364 · NIDA · UNIVERSITY OF KENTUCKY · PI LILE, JOSHUA ANTHONY · 2013 to 2016
$1.9M
Targeting GABA and Opioid Systems for a Pharmacotherapy for Methamphetamine AbuseR01DA033394 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2013 to 2015
$1.8M
Agonist Replacement Therapy for Methamphetamine Dependence: Human Lab StudiesR01DA025032 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2009 to 2013
$1.8M
Selective Monoamine Release as a Treatment for Cocaine Use DisordersR01DA036553 · NIDA · UNIVERSITY OF KENTUCKY · PI STOOPS, WILLIAM WALTON · 2014 to 2017
$1.6M
Motivation for Cocaine and Non-Drug Reinforcers: Targeting Glutamate HomeostasisR21DA035376 · NIDA · UNIVERSITY OF KENTUCKY · PI STOOPS, WILLIAM WALTON · 2014 to 2015
$376k
Buspirone as a Candidate Medication for Methamphetamine AbuseR21DA035481 · NIDA · UNIVERSITY OF KENTUCKY · PI RUSH, CRAIG R · 2013 to 2014
$374k
A Human Laboratory Study to Investigate Buspirone for Cocaine Use DisordersR21DA034095 · NIDA · UNIVERSITY OF KENTUCKY · PI STOOPS, WILLIAM WALTON · 2012 to 2013
$363k
NIDA NIH HHS R01 DA025032NIDA NIH HHS R01 DA032254NIDA NIH HHS R01 DA033364NIDA NIH HHS R01 DA033394NIDA NIH HHS R01 DA036553NIDA NIH HHS R01 DA036827NIDA NIH HHS R21 DA034095NIDA NIH HHS R21 DA035376NIDA NIH HHS R21 DA035481NIDA NIH HHS T32 DA035200
6 · The paper itself

Abstract

backgroundDisrupted response inhibition and presence of drug-cue attentional bias in cocaine-using individuals have predicted poor treatment outcomes. Inhibitory control training could help improve treatment outcomes by strengthening cognitive control. This pilot study assessed the effects of acute inhibitory control training to drug- and non-drug-related cues on response inhibition performance and cocaine-cue attentional bias in cocaine-using individuals.

methodsParticipants who met criteria for a cocaine-use disorder underwent five sessions of inhibitory control training to either non-drug-related cues (i.e., rectangles) or cocaine cues (n=10/condition) in a single day. Response inhibition and attentional bias were assessed prior to and following training using the stop-signal task and visual-probe task with eye tracking, respectively.

resultsTraining condition groups did not differ on demographics, inhibitory control training performance, response inhibition, or cocaine-cue attentional bias. Response inhibition performance improved as a function of inhibitory control training in both conditions. Cocaine-cue attentional bias was observed, but did not change as a function of inhibitory control training in either condition.

conclusionsResponse inhibition in cocaine-using individuals was augmented by acute inhibitory control training, which may improve treatment outcomes through better behavioral inhibition. Future studies should investigate longer-term implementation of inhibitory control training, as well as combining inhibitory control training with other treatment modalities.

Indexed as

Inhibition, PsychologicalAdultAttentionBehavior TherapyCocaine-Related DisordersCuesDrug UsersExecutive FunctionFemaleHumansMaleMiddle AgedNeuropsychological TestsPilot ProjectsTreatment OutcomeAttentional biasCocaine-use disordersInhibitory control trainingResponse inhibition

Identifiers

PMID28329718
PMCPMC5400705

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.