Evidence map›Paper›PMID 28329691›Full record

ArticleCell reports2017

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells.

Katrien Van der Borght, Charlotte L Scott, Veronika Nindl, Ann Bouché, Liesbet Martens, Dorine Sichien, Justine Van Moorleghem, Manon Vanheerswynghels, Sofie De Prijck, Yvan Saeys and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Pooled it
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  17. B cells promote atrial fibrillation via autoantibodies.Nature cardiovascular research · 2025
    Article
  18. Article
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  20. Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Katrien Van der BorghtImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium.
Charlotte L ScottImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Veronika NindlInstitute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
Ann BouchéVIB Vesalius Research Center, 3000 Leuven, Belgium.
Liesbet MartensImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Dorine SichienImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Justine Van MoorleghemImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium.
Manon VanheerswynghelsImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium.
Sofie De PrijckImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Yvan SaeysImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Burkhard LudewigInstitute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
Thierry GillebertDepartment of Internal Medicine, Ghent University, 9000 Ghent, Belgium.
Martin GuilliamsImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Peter CarmelietVIB Vesalius Research Center, 3000 Leuven, Belgium. Electronic address: peter.carmeliet@vib-kuleuven.be.
Bart N LambrechtImmunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Internal Medicine, Ghent University, 9000 Ghent, Belgium; Department of Pulmonary Medicine, ErasmusMC, 3015 Rotterdam, the Netherlands. Electronic address: bart.lambrecht@ugent.be.
VIB-UGent Center for Inflammation Research · BEGhent University · BEKantonsspital St. Gallen · CHVIB-KU Leuven Center for Microbiology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral tolerance is crucial for avoiding activation of self-reactive T cells to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it is unclear how autoreactive T cells get activated in response to self. An example of a sterile injury is myocardial infarction (MI). We hypothesized that tissue necrosis is an activator of dendritic cells (DCs), which control tolerance to self-antigens. DC subsets of a murine healthy heart consisted of IRF8-dependent conventional (c)DC1, IRF4-dependent cDC2, and monocyte-derived DCs. In steady state, cardiac self-antigen α-myosin was presented in the heart-draining mediastinal lymph node (mLN) by cDC1s, driving the proliferation of antigen-specific CD4

Indexed as

AnimalsCD11c AntigenCD4-Positive T-LymphocytesCell MovementDendritic CellsInterferon Regulatory Factor-8Interferon Regulatory FactorsLymph NodesMice, Inbred BALB CMice, Inbred C57BLMonocytesMyocardial InfarctionMyocardiumMyosinsPhenotypeT-LymphocytesCD11c AntigenInterferon Regulatory Factor-8Interferon Regulatory FactorsMyosinsTranscription Factorsautoimmunitycardiac myosindendritic cellgene expressionheartIRF4IRF8myocardial infarctiontissue necrosistolerance

Identifiers

PMID28329691
PMCPMC5379012
OpenAlexW2601528168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.