ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Clinical Significance of Human Coronavirus in Bronchoalveolar Lavage Samples From Hematopoietic Cell Transplant Recipients and Patients With Hematologic Malignancies.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence.BMC infectious diseases · 2020Pooled it
- Incidence, significance, and persistence of human coronavirus infection in hematopoietic stem cell transplant recipients.Bone marrow transplantation · 2019Trial
- A decade of endemic human coronaviruses: epidemiological patterns and clinical significance in an adult cohort at a tertiary care hospital in Germany.BMC infectious diseases · 2026Article
- Co-detection of measles virus vaccine strain and seasonal coronavirus in an immunocompromised patient with pneumonia.ASM case reports · 2026Article
- Severe HCoV-OC43 Pneumonia in a 25-Year-Old Woman Following Allogeneic Hematopoietic Stem Cell Transplantation.The clinical respiratory journal · 2026Article
- Review
- Are any specific respiratory viruses more severe than others in recipients of allogeneic stem cell transplantation? A focus on lower respiratory tract disease.Bone marrow transplantation · 2024Article
- Respiratory viruses in hematopoietic cell transplant candidates: impact of preexisting lower tract disease on outcomes.Blood advances · 2022Article
- Predicting risk of progression to lower respiratory tract infection in allogeneic hematopoietic cell transplant recipients with respiratory viral infections: where are we now?Bone marrow transplantation · 2022Article
- Non-COVID-19 respiratory viral infection.Breathe (Sheffield, England) · 2022Review
- Clinical characteristics and outcomes of lung cancer patients with COVID-19: A systematic review and meta-analysis protocol.PloS one · 2022Article
- Clinical outcomes in cancer patients with COVID-19.Cancer reports (Hoboken, N.J.) · 2021Article
- Article
- Risk factors for seasonal human coronavirus lower respiratory tract infection after hematopoietic cell transplantation.Blood advances · 2021Article
- Epidemiology and clinical features of common community human coronavirus disease.Journal of thoracic disease · 2021Article
- Burden of noninfluenza respiratory viral infections in adults admitted to hospital: analysis of a multiyear Canadian surveillance cohort from 2 centres.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Article
- COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnology.International immunopharmacology · 2021Review
- SARS-CoV-2 infections in children and young people.Clinical immunology (Orlando, Fla.) · 2020Review
- Coronavirus in Hematologic Malignancies: Targeting Molecules Beyond the Angiotensin-Converting Enzyme 2 (ACE2) Wall in COVID-19.Pathology oncology research : POR · 2020Article
- Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation.The New England journal of medicine · 2020Article
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
Abstract
BACKGROUND.: The possible role of human coronavirus (HCoV) in lower respiratory tract disease (LRTD) in hematopoietic cell transplant (HCT) recipients and patients with hematologic malignancies (HM) has not been well studied. METHODS.: We conducted a retrospective review of HCT/HM patients with HCoV detected in bronchoalveolar lavage (BAL). HCoV strains were identified in BAL samples using strain-specific polymerase chain reaction. Mortality rates were compared among HCT recipients with LRTD caused by HCoV, respiratory syncytial virus (RSV), influenza virus, or parainfluenza virus (PIV) by multivariable Cox regression analysis. RESULTS.: We identified 35 patients (37 episodes) with HCoV LRTD. Among 23 available BAL samples, 48% were strain OC43, 22% were NL63, 17% were 229E, and 13% were HKU1. Overall, 21 patients (60%) required oxygen therapy at diagnosis and 19 (54%) died within 90 days of diagnosis. Respiratory copathogens were detected in 21 episodes (57%), including viruses (n = 12), fungi (n = 10), and bacteria (n = 8). Mortality rates were not different between patients with and without copathogens (P = .65). In multivariable models, mortality associated with HCoV LRTD was similar to that seen with RSV, influenza, and PIV LRTD in HCT recipients (adjusted hazard ratio, 1.34 [95% confidence interval, .66-2.71], P = .41 vs RSV, adjusted for cell source, cytopenia, copathogens, oxygen use, and steroid use). CONCLUSIONS.: HCoV LRTD in patients with HCT or HM is associated with high rates of oxygen use and mortality. Mortality associated with HCoV LRTD in HCT recipients appears to be similar to that seen with RSV, influenza virus, and PIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.