ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Outcome and Treatment of Nocardiosis After Solid Organ Transplantation: New Insights From a European Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07013006 (Retrospective Study to Assess the Evolution of MRI or CT Lesions in Treated CNS Nocardiosis), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retrospective Study to Assess the Evolution of MRI or CT Lesions in Treated CNS Nocardiosis
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Clinical Characteristics and Treatment Outcome of Central Nervous System Nocardiosis: A Systematic Review of Reported Cases.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Pooled it
- Nocardiosis Associated with Primary Immunodeficiencies (Nocar-DIP): an International Retrospective Study and Literature Review.Journal of clinical immunology · 2020Pooled it
- Risk factors for mortality after nocardiosis in Southern France (2014-2024).IJID regions · 2026Article
- Imaging characteristics, yield of computed tomography, and clinical outcomes of central nervous system nocardiosis.Infection · 2026Article
- Synergistic and additive in vitro interactions of imipenem, trimethoprim-sulfamethoxazole, amikacin, and clofazimine against clinical isolates of Nocardia wallacei.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Risk Factors and Outcomes of Disseminated Nocardiosis Across Host Risk Groups.Open forum infectious diseases · 2026Article
- The global epidemiology, risk factors, and mortality prediction of nocardiosis: an easily missed opportunistic infection.Scientific reports · 2025Article
- The Diagnostic Challenges of Disseminated Nocardiosis in a Post-Renal Transplant Patient: A Case Report.Reports (MDPI) · 2025Article
- Shorter vs. standard-duration antibiotic therapy for nocardiosis: a multi-center retrospective cohort study.Infection · 2025Article
- Ultrasound-guided thoracentesis for diagnosingRadiology case reports · 2025Article
- Case Report: Bloodstream infection withFrontiers in medicine · 2025Article
- First Documented Case of Pneumonia withInfection and drug resistance · 2025Article
- Investigation of Risk Factors and Development of Clinical Prediction Model for Nocardiosis in Lung Transplant Recipients.Infection and drug resistance · 2025Article
- Nocardia masquerading as pulmonary malignancy in a patient with adult-onset immunodeficiency onRadiology case reports · 2024Article
- Guidelines for Antibiotics Prescription in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Article
- Epidemiology, Timing, and Secondary Prophylaxis of Recurrent Nocardiosis.Open forum infectious diseases · 2024Article
- Article
- Comparative Analysis of CT Findings and Clinical Outcomes in Adult Patients With Disseminated and Localized Pulmonary Nocardiosis.Journal of Korean medical science · 2024Article
- Critically Ill Patients with Visceral Nocardia Infection, France and Belgium, 2004-2023.Emerging infectious diseases · 2024Article
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
21 authors at 15 institutions in 5 countries.
Funding
Abstract
backgroundSolid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with 1-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days).
methodsWe analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with 1-year all-cause mortality were identified using multivariable conditional logistic regression.
resultsOne-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, P < .001). A history of tumor (odds ratio [OR], 1.4; 95% confidence interval [CI], 1.1-1.8), invasive fungal infection (OR, 1.3; 95% CI, 1.1-1.5), and donor age (OR, 1.0046; 95% CI, 1.0007-1.0083) were independently associated with 1-year mortality. Acute rejection in the year before nocardiosis was associated with improved survival (OR, 0.85; 95% CI, 0.73-0.98). Seventeen patients received short-course antibiotics (median duration 56 [24-120] days) with a 1-year success rate (cured and surviving) of 88% and a 5.9% risk of relapse (median follow-up 49 [6-136] months).
conclusionsOne-year mortality was 10-fold higher in SOT patients with nocardiosis than in those without. Four factors, largely reflecting general medical condition rather than severity and/or management of nocardiosis, were independently associated with 1-year mortality. Patients who received short-course antibiotic treatment had good outcomes, suggesting that this may be a strategy for further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.