Evidence map›Paper›PMID 28329303›Full record

ArticleThe Journal of infectious diseases2017

High Burden of Antimicrobial Resistance and Mortality Among Adults and Children With Community-Onset Bacterial Infections in India.

Vidya Mave, Ajay Chandanwale, Anju Kagal, Sandhya Khadse, Dileep Kadam, Renu Bharadwaj, Vaishali Dohe, Matthew L Robinson, Aarti Kinikar, Samir Joshi and 11 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  9. Observational
  10. Review
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  12. Observational
  13. Review
  14. Multi-drug resistance ofIranian journal of pharmaceutical research : IJPR · 2020
    Article
  15. The Mortality Burden of Multidrug-resistant Pathogens in India: A Retrospective, Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Observational
  16. Article
  17. Article
  18. Article
  19. Antibiotic Utilization and the Role of Suspected and Diagnosed Mosquito-borne Illness Among Adults and Children With Acute Febrile Illness in Pune, India.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  20. Vector-Borne Disease is a Common Cause of Hospitalized Febrile Illness in India.The American journal of tropical medicine and hygiene · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Vidya MaveJohns Hopkins University School of Medicine, Baltimore, Maryland.
Ajay ChandanwaleJohns Hopkins University School of Medicine, Baltimore, Maryland.
Anju KagalJohns Hopkins University School of Medicine, Baltimore, Maryland.
Sandhya KhadseJohns Hopkins University School of Medicine, Baltimore, Maryland.
Dileep KadamJohns Hopkins University School of Medicine, Baltimore, Maryland.
Renu BharadwajJohns Hopkins University School of Medicine, Baltimore, Maryland.
Vaishali DoheJohns Hopkins University School of Medicine, Baltimore, Maryland.
Matthew L RobinsonJohns Hopkins University School of Medicine, Baltimore, Maryland.
Aarti KinikarJohns Hopkins University School of Medicine, Baltimore, Maryland.
Samir JoshiJohns Hopkins University School of Medicine, Baltimore, Maryland.
Priyanka RaichurJohns Hopkins University School of Medicine, Baltimore, Maryland.
Katie McIntireJohns Hopkins University School of Medicine, Baltimore, Maryland.
Savita KanadeJohns Hopkins University School of Medicine, Baltimore, Maryland.
Jonathan SachsTulane University School of Medicine, New Orleans, Louisiana.
Chhaya ValviByramjee Jeejeebhoy Government Medical College, Pune, India.
Usha BalasubramanianJohns Hopkins University School of Medicine, Baltimore, Maryland.
Vandana KulkarniJohns Hopkins University School of Medicine, Baltimore, Maryland.
Aaron M MilstoneJohns Hopkins University School of Medicine, Baltimore, Maryland.
Ivan MarbaniangJohns Hopkins University School of Medicine, Baltimore, Maryland.
Jonathan ZenilmanJohns Hopkins University School of Medicine, Baltimore, Maryland.
Amita GuptaJohns Hopkins University School of Medicine, Baltimore, Maryland.

Funding

RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Byramee Jeejeebhoy Medical College (BJMC), Pune, India: Clinical Trials UnitU01AI069497 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GUPTA, AMITA · 2007 to 2011
$4.1M
FIC NIH HHS R25 TW009340NIAID NIH HHS T32 AI007291NIAID NIH HHS U01 AI069497
6 · The paper itself

Abstract

Background: In India, antimicrobial consumption is high, yet systematically collected data on the epidemiology, risk factors, and outcomes of antimicrobial-resistant infections are limited. Methods: A prospective study of adults and children hospitalized for acute febrile illness was conducted between August 2013 and December 2015. In-hospital outcomes were recorded, and logistic regression was performed to identify independent predictors of community-onset antimicrobial-resistant infections. Results: Among 1524 patients hospitalized with acute febrile illness, 133 isolates were found among 115 patients with community-onset infections; 66 isolates (50.0%) were multidrug resistant and, of 33 isolates tested for carbapenem susceptibility, 12 (36%) were resistant. Multidrug-resistant infections were associated with recent antecedent antibiotic use (adjusted odds ratio [aOR], 4.17; 95% confidence interval [CI], 1.19-19.7) and were independently associated with mortality (aOR, 6.06; 95% CI, 1.2-55.7). Conclusion: We found a high burden of community-onset antimicrobial-resistant infection among patients with acute febrile illness in India. Multidrug-resistant infection was associated with prior antibiotic use and an increased risk of mortality.

Indexed as

Drug Resistance, Multiple, BacterialHospital MortalityAcute DiseaseAdolescentAdultAnti-Bacterial AgentsBacteriaBacterial InfectionsChildChild, PreschoolCross InfectionFemaleHumansIndiaLength of StayLogistic ModelsAnti-Bacterial Agentsantimicrobial resistanceclinical isolatescommunity onsetIndia.

Identifiers

PMID28329303
PMCPMC5853545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.