ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
A Modified Healthy Aging Index and Its Association with Mortality: The National Health and Nutrition Examination Survey, 1999-2002.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The Relationship Between Successful Aging and All-Cause Mortality Risk in Older Adults: A Systematic Review and Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial.The journal of nutrition, health & aging · 2022Trial
- Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- What Makes for Healthy Ageing in the Torres Strait?The Australian journal of rural health · 2025Article
- Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants.GeroScience · 2024Article
- Measuring healthy ageing: current and future tools.Biogerontology · 2023Review
- Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease.Journal of the American Heart Association · 2023Article
- Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study.BMC geriatrics · 2023Article
- Construction of healthy aging index from two different datasets.Frontiers in public health · 2023Article
- The association between healthy aging index and trajectories of disability: a population-based cohort study.Aging clinical and experimental research · 2022Article
- Combined association of cognitive impairment and poor oral health on mortality risk in older adults: Results from the NHANES with 15 years of follow-up.Journal of periodontology · 2022Article
- Development and Validation of a Multidimensional Population-Based Healthy Aging Scale: Results From the China Health and Retirement Longitudinal Study.Frontiers in medicine · 2022Article
- Subclinical Vascular Disease Burden and Premature Mortality Among Middle-aged Adults: the Atherosclerosis Risk in Communities Study.Journal of general internal medicine · 2021Article
- The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study.BMC geriatrics · 2021Article
- Quantifying and Classifying Physical Resilience Among Older Adults: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Healthy ageing and the prediction of mortality and incidence dependence in low- and middle- income countries: a 10/66 population-based cohort study.BMC medical research methodology · 2019Article
- Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging, and Body Composition Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Does Religion Predict Health-Promoting Behaviors in Community-Dwelling Elderly People?Journal of religion and health · 2019Article
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.GeroScience · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundComorbidity indices that are based on clinically recognized disease do not capture the full spectrum of health. The Healthy Aging Index (HAI) was recently developed to describe a wider range of health and disease across multiple organ systems. We characterized the distribution of a modified HAI (mHAI) by sociodemographics in a representative sample of the U.S. population. We also examined the association of the mHAI with mortality across individuals with different levels of clinically recognizable comorbidities.
methodsData are from the National Health and Nutrition Examination Survey (1999-2000, 2001-2002) on 2,451 adults aged 60 years or older. Five mHAI components (systolic blood pressure, Digit Symbol Substitution Test, cystatin C, glucose, and respiratory problems) were scored 0 (healthiest), 1, or 2 (unhealthiest) by sex-specific tertiles or clinically relevant cutoffs and summed to construct the mHAI.
resultsThe mean mHAI score was 4.3; 20.6% had a score of 0-2. 33.2% had a score of 3-4, 31.0% had a score of 5-6, and 15.2% had a score of 7-10. Mean mHAI scores were lower in adults who were younger, non-Hispanic whites, more educated, and married/living with partner. After multivariate adjustment, per unit higher of the mHAI was associated with higher all-cause mortality (HR = 1.19, 95% CI = 1.11-1.27) and higher cardiovascular mortality (HR = 1.23, 95% CI = 1.11-1.35). Within each comorbidity category (0, 1, 2, 3, 4+), the mHAI was still widely distributed and further stratified mortality.
conclusionsSubstantial variation exists in the mHAI across sociodemographic subgroups. The mHAI could provide incremental value for mortality risk prediction beyond clinically diagnosed chronic diseases among elders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.