ArticleThe Journal of infectious diseases2017
Lethal CD4 T Cell Responses Induced by Vaccination Against Staphylococcus aureus Bacteremia.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Methicillin-resistant and susceptible Staphylococcus aureus: tolerance, immune evasion and treatment.Nature reviews. Microbiology · 2026Review
- Overcoming Immune Evasion inACS infectious diseases · 2025Review
- Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses.Nature communications · 2024Article
- Intertwining clonality and resistance: Staphylococcus aureus in the antibiotic era.The Journal of clinical investigation · 2024Article
- Conserved moonlighting protein pyruvate dehydrogenase induces robust protection againstProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Superantigens promoteProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection.The Journal of infectious diseases · 2022Observational
- Safety and Immunogenicity of a 4-Component Toxoid-BasedFrontiers in immunology · 2021Article
- Evasion of Immunological Memory byFrontiers in immunology · 2021Review
- IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused byFrontiers in immunology · 2021Article
- Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.FEMS microbiology reviews · 2020Review
- Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.PLoS pathogens · 2019Article
- Immunity toMicrobiology spectrum · 2019Review
- TBAScientific reports · 2019Article
- A Critical Role for HlgA inToxins · 2018Article
- Vaccine display on artificial bacterial spores enhances protective efficacy against Staphylococcus aureus infection.FEMS microbiology letters · 2018Article
- Two Vaccines formSphere · 2018Article
- Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection.The Journal of clinical investigation · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Multiple candidate vaccines against Staphylococcus aureus infections have failed in clinical trials. Analysis of a recent prematurely halted vaccine trial revealed increased mortality rates among vaccine recipients in whom postsurgical S. aureus infection developed, emphasizing the potential for induction of detrimental immune responses and the need to better understand the requirements for protective immunity against S. aureus. These failures of single-antigen vaccines have prompted ongoing development of multicomponent vaccines to target the multitude of S. aureus virulence factors. In the current study, we used lethally irradiated S. aureus as a model multicomponent vaccine and showed that vaccination of mice decreased survival in a bacteremia challenge model. These deleterious effects were due to a CD4 T-cell-dependent interferon γ response and could be prevented by inhibiting development of this response during vaccination. Our results identify the potential for vaccination to induce pathological immune responses, and they have implications for recent vaccine failures and the design of future staphylococcal vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.