Evidence map›Paper›PMID 28329204›Full record

ReviewSleep2017

New Neuroscience Tools That Are Identifying the Sleep-Wake Circuit.

Priyattam J Shiromani, John H Peever

Abstract readReview
In one paragraph

Review in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Mapping Network Activity in Sleep.Frontiers in neuroscience · 2021
    Review
  6. Review
  7. Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Priyattam J ShiromaniRalph H. Johnson Veterans Administration Medical Center, Research Service, Charleston, SC.
John H PeeverCentre for Biological Timing and Cognition, Department Cell and Systems Biology, and Physiology, University of Toronto, Toronto, ON, Canada.

Funding

Melanin Concentrating Hormone Neurons in SleepR01NS052287 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2006 to 2018
$3.4M
Astroglia-Neuron Regulation of SleepR21NS098541 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2016 to 2017
$411k
Astroglial Orexin in Sleep DisordersR21NS084477 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIROMANI, PRIYATTAM J. · 2013 to 2014
$409k
Sleep Neurobiology and CircuitryI01BX000798 · VA · VA BOSTON HEALTH CARE SYSTEM · PI HOWARD C. BECKER · 2011 to 2026
–
BLRD VA I01 BX000798NINDS NIH HHS R01 NS052287NINDS NIH HHS R21 NS084477NINDS NIH HHS R21 NS098541
6 · The paper itself

Abstract

The complexity of the brain is yielding to technology. In the area of sleep neurobiology, conventional neuroscience tools such as lesions, cell recordings, c-Fos, and axon-tracing methodologies have been instrumental in identifying the complex and intermingled populations of sleep- and arousal-promoting neurons that orchestrate and generate wakefulness, NREM, and REM sleep. In the last decade, new technologies such as optogenetics, chemogenetics, and the CRISPR-Cas system have begun to transform how biologists understand the finer details associated with sleep-wake regulation. These additions to the neuroscience toolkit are helping to identify how discrete populations of brain cells function to trigger and shape the timing and transition into and out of different sleep-wake states, and how glia partner with neurons to regulate sleep. Here, we detail how some of the newest technologies are being applied to understand the neural circuits underlying sleep and wake.

Indexed as

AnimalsBrainCRISPR-Cas SystemsHumansNeurogliaNeuronsNeurosciencesOptogeneticsSleepSleep, REMWakefulnessCellular and molecular biologychemogeneticsnarcolepsyoptogeneticsREM sleepsleep.

Identifiers

PMID28329204
PMCPMC6084767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.