ArticleThe Journal of infectious diseases2017
Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood.
Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Maternal microchimerism at birth associates with reduced odds of non-malarial fever and respiratory tract infections in Tanzanian children.PLOS global public health · 2026Article
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- From Womb to World: Exploring the Immunological Connections between Mother and Child.ImmunoHorizons · 2024Review
- The 'communicatome' of pregnancy: spotlight on cellular and extravesicular chimerism.EMBO molecular medicine · 2024Review
- Pregnancy-induced transfer of pathogen-specific T cells from mother to fetus in mice.EMBO reports · 2023Article
- Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Transplacental transfer of total immunoglobulin G and antibodies to Plasmodium falciparum antigens between the 24th week of gestation and term.Scientific reports · 2022Article
- Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity.The Journal of clinical investigation · 2022Article
- Altered Offspring Immunity in Maternal Parasitic Infections.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated With Increased Maternal Microchimerism in the Offspring.The Journal of infectious diseases · 2021Article
- Predictors of maternal-origin microchimerism in young women in the Philippines.American journal of physical anthropology · 2021Article
- The significance of the placental genome and methylome in fetal and maternal health.Human genetics · 2020Review
- Optimization of Chelex 100 resin-based extraction of genomic DNA from dried blood spots.Biology methods & protocols · 2020Article
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Article
- Developmental origin and sex-specific risk for infections and immune diseases later in life.Seminars in immunopathology · 2019Review
- In utero priming of highly functional effector T cell responses to human malaria.Science translational medicine · 2018Article
- Human fetal immune cells fight back.Science translational medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Background: A mother's infection with placental malaria (PM) can affect her child's susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a small amount of maternal cells and DNA known as maternal microchimerism (MMc), and we hypothesized that PM increases MMc and that MMc alters risk of Plasmodium falciparum malaria during infancy. Methods: In a nested cohort from Muheza, Tanzania, we evaluated the presence and level of cord blood MMc in offspring of women with and without PM. A maternal-specific polymorphism was identified for each maternal-infant pair, and MMc was assayed by quantitative polymerase chain reaction. The ability of MMc to predict malaria outcomes during early childhood was evaluated in longitudinal models. Results: Inflammatory PM increased the detection rate of MMc among offspring of primigravidae and secundigravidae, and both noninflammatory and inflammatory PM increased the level of MMc. Detectable MMc predicted increased risk of positive blood smear but, interestingly, decreased risk of symptomatic malaria and malaria hospitalization. Conclusions: The acquisition of MMc may result in increased malaria infection but protection from malaria disease. Future studies should be directed at the cellular component of MMc, with attention to its ability to directly or indirectly coordinate anti-malarial immune responses in the offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.