ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Prediction of Long-term Cognitive Decline Following Postoperative Delirium in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.Journal of Alzheimer's disease : JAD · 2020Trial
- Motor Imagery during Action Observation of Locomotor Tasks Improves Rehabilitation Outcome in Older Adults after Total Hip Arthroplasty.Neural plasticity · 2018Trial
- Long-Term Cognitive and Functional Outcomes Following Postoperative Delirium and Liberal Fluid Fasting in Elderly Trauma Patients: A Prospective Single-Centre Study.Journal of clinical medicine · 2026Article
- Impact of CGA and Surgical Risk Calculator before elective cancer surgery on postoperative delirium in elderly patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Postoperative Delirium: A Survey of Perceptions Among Surgical Providers.Delirium (Bielefeld, Germany) · 2026Article
- Postoperative delirium in patients with cancer: a narrative review of major risk factors.Sao Paulo medical journal = Revista paulista de medicina · 2026Review
- Delirium is associated with incident dementia across the multimorbidity spectrum: a population-based cohort study.medRxiv : the preprint server for health sciences · 2025Article
- Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit.Scientific reports · 2025Article
- Anesthetics and Postoperative Delirium in Elderly after Elective Surgery: A Retrospective Comparison between Sevoflurane and Propofol.Medical journal of the Islamic Republic of Iran · 2025Article
- The interrelationship between multiple long-term conditions (MLTC) and delirium: a scoping review.Age and ageing · 2024Article
- The Mediating Role of Proxy Respondents on the Relationship Between Cognitive Function and Self-Rated Health.The Gerontologist · 2024Article
- Article
- The effect of baseline cognition and delirium on long-term cognitive impairment and mortality: a prospective population-based study.The lancet. Healthy longevity · 2022Article
- Major Surgery and Long Term Cognitive Outcomes: The Effect of Postoperative Delirium on Dementia in the Year Following Discharge.The Journal of surgical research · 2022Article
- Association of Subjective Cognitive Decline With Postoperative Complications Could Herald Dementia Risk.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients.Journal of general internal medicine · 2021Observational
- Impaired Executive Function and Depression as Independent Risk Factors for Reported Delirium Symptoms: An Observational Cohort Study Over 8 Years.Frontiers in aging neuroscience · 2021Article
- Time course of dementia following sepsis in German health claims data.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies.Journal of the American Geriatrics Society · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIncreasing evidence suggests that postoperative delirium may result in long-term cognitive decline among older adults. Risk factors for such cognitive decline are unknown.
methodsWe studied 126 older participants without delirium or dementia upon entering the Successful AGing After Elective Surgery (SAGES) study, who developed postoperative delirium and completed repeated cognitive assessments (up to 36 months of follow-up). Pre-surgical factors were assessed preoperatively and divided into nine groupings of related factors ("domains"). Delirium was evaluated at baseline and daily during hospitalization using the Confusion Assessment Method diagnostic algorithm, and cognitive function was assessed using a neuropsychological battery and the Informant Questionnaire for Cognitive Decline in the Elderly (IQCODE) at baseline and 6-month intervals over 3 years. Linear regression was used to examine associations between potential risk factors and rate of long-term cognitive decline over time. A domain-specific and then overall selection method based on adjusted R2 values was used to identify explanatory factors for the outcome.
resultsThe General Cognitive Performance (GCP) score (combining all neuropsychological test scores), IQCODE score, and living alone were significantly associated with long-term cognitive decline. GCP score explained the most variation in rate of cognitive decline (13%), and six additional factors-IQCODE score, cognitive independent activities of daily living impairment, living alone, cerebrovascular disease, Charlson comorbidity index score, and exhaustion level-in combination explained 32% of variation in this outcome.
conclusionsGlobal cognitive performance was most strongly associated with long-term cognitive decline following delirium. Pre-surgical factors may substantially predict this outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.