ReviewSleep2017
Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.
Review in Sleep, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Treatments for sleep disturbances in individuals with acquired brain injury: A systematic review.Clinical rehabilitation · 2021Pooled it
- Concussion Guidelines Step 2: Evidence for Subtype Classification.Neurosurgery · 2020Guideline
- Trial
- The growing gap: A study of sleep, encoding, and consolidation of new words in chronic traumatic brain injury.Neuropsychologia · 2023Trial
- A short add-on sleep intervention in the rehabilitation of individuals with acquired brain injury: A randomized controlled trial.NeuroRehabilitation · 2023Trial
- Trial
- Primary Blast-Induced Traumatic Brain Injury as a Risk Factor for (Cerebro)vascular Disorder: Clinical Manifestations, Blast Physics, Biomechanics, Pathobiology, and Critical Gaps.International journal of molecular sciences · 2026Review
- Article
- Sleep Disturbance Trajectories in Critically Ill Children Post-ICU Discharge: A Longitudinal Observational Study.Children (Basel, Switzerland) · 2026Article
- Sleep fragmentation intensifies sleep architecture disruption and fatigue after traumatic brain injury.Experimental neurology · 2026Article
- Acute sleep deprivation alters hypothalamic neuroinflammatory signaling independent of traumatic brain injury in the mouse.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Sleep and adaptation disorders in military personnel with blast injury.BMJ military health · 2025Article
- Perceiving traumatic brain injury from glymphatic system.Molecular psychiatry · 2025Review
- Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions.Pharmacological reviews · 2025Review
- Lipoxins as Modulators of Diseases.Cells · 2025Review
- Network effects of traumatic brain injury: from infra slow to high frequency oscillations and seizures.Journal of computational neuroscience · 2025Article
- Impacts of traumatic brain injury severity and sex on sleep architecture, duration, and fragmentation.Neurobiology of sleep and circadian rhythms · 2025Article
- The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models.Frontiers in neurology · 2025Review
- Sleep spindle density and morphology are resilient to post-traumatic gray matter volume loss.NeuroImage. Clinical · 2025Article
- Effects of Traumatic Brain Injury on the Orexin/Hypocretin System.Neurotrauma reports · 2025Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of life. Recently, there has been a nearly exponential increase in the number of primary research articles published on the pathophysiology and mechanisms underlying sleep-wake disturbances after TBI, both in animal models and in humans, including in the pediatric population. In this review, we summarize over 200 articles on the topic, most of which were identified objectively using reproducible online search terms in PubMed. Although these studies differ in terms of methodology and detailed outcomes; overall, recent research describes a common phenotype of excessive daytime sleepiness, nighttime sleep fragmentation, insomnia, and electroencephalography spectral changes after TBI. Given the heterogeneity of the human disease phenotype, rigorous translation of animal models to the human condition is critical to our understanding of the mechanisms and of the temporal course of sleep-wake disturbances after injury. Arguably, this is most effectively accomplished when animal and human studies are performed by the same or collaborating research programs. Given the number of symptoms associated with TBI that are intimately related to, or directly stem from sleep dysfunction, sleep-wake disorders represent an important area in which mechanistic-based therapies may substantially impact recovery after TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.