ArticlePloS one2017
Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Pathogen diversity in mosquitoes (Diptera: Culicidae) from the Republic of Kosovo: a two-year cross-sectional study.New microbes and new infections · 2026Article
- Blechomonas campbelli from Ctenocephalides felis: in vitro development, thermotolerance, and phylogenetic insights.Memorias do Instituto Oswaldo Cruz · 2026Article
- Diversity of RNA viruses in the cosmopolitan monoxenous trypanosomatid Leptomonas pyrrhocoris.BMC biology · 2023Article
- Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae.BMC genomics · 2023Article
- Natural infection withFrontiers in microbiology · 2023Article
- The Roles of Mosquitoes in the Circulation of Monoxenous Trypanosomatids in Temperate Climates.Pathogens (Basel, Switzerland) · 2022Article
- Trypanosomatid Richness Among Rats, Opossums, and Dogs in the Caatinga Biome, Northeast Brazil, a Former Endemic Area of Chagas Disease.Frontiers in cellular and infection microbiology · 2022Article
- Catalase impairsVirulence · 2021Article
- Genomics of Trypanosomatidae: Where We Stand and What Needs to Be Done?Pathogens (Basel, Switzerland) · 2021Review
- A New Model Trypanosomatid,mBio · 2021Article
- Article
- Catalase and Ascorbate Peroxidase in Euglenozoan Protists.Pathogens (Basel, Switzerland) · 2020Article
- First Draft Genome of the TrypanosomatidTropical medicine and infectious disease · 2020Article
- Analysing ambiguities in trypanosomatids taxonomy by barcoding.Memorias do Instituto Oswaldo Cruz · 2020Article
- Article
- Molecular Identification of Species Caused Cutaneous Leishmaniasis in Southern Zone of Iran.Journal of arthropod-borne diseases · 2019Article
- Bionomics of phlebotomine sand flies species (Diptera: Psychodidae) and their natural infection withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- RNA Viruses inmBio · 2018Article
- Article
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19 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growth kinetics, and transcriptomic profiles of flagellates cultivated at low (23°C) and elevated (34°C) temperature. When maintained at high temperature, they grew significantly faster, became shorter, with genes involved in sugar metabolism and mitochondrial stress protection significantly upregulated. Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern. This disparity illustrates differences in the biology of these two parasites and distinct mechanisms of their thermotolerance, a prerequisite for living in warm-blooded vertebrates.
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