ArticlePloS one2017
Thickness of retinal layers in the foveas of children with anisometropic amblyopia.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- "OCT based retinal changes in amblyopia: A systematic review".Journal of optometryPooled it
- Macular, Foveal and RNFL Thickness Patterns in Amblyopia: A Comparative Study.Clinical optometry · 2026Article
- Changes in peripapillary retinal nerve fiber layer thickness, macular fovea thickness, and perimacular retinal nerve fiber layer thickness in children with hyperopic amblyopia.American journal of translational research · 2026Article
- The Relationship between Fixation Stability and Retinal Structural Parameters in Children with Anisometropic, Strabismic and Mixed Amblyopia.Life (Basel, Switzerland) · 2023Article
- Long-term effects of early/late-onset visual deprivation on macular and retinal nerve fibers layer structure: A pilot study.PloS one · 2023Article
- Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses.Investigative ophthalmology & visual science · 2021Article
- Thicknesses of Macular Inner Retinal Layers in Children with Anisometropic Amblyopia.BioMed research international · 2020Article
- Changes in macular ultrastructural morphology in unilateral anisometropic amblyopia.American journal of translational research · 2019Article
- Macular Thickness in Moderate to Severe Amblyopia.Korean journal of ophthalmology : KJO · 2018Article
- Lamina cribrosa thickness in children with hyperopic anisometropic amblyopia.International journal of ophthalmology · 2018Article
- Evaluation of optical coherence tomography findings according to treatment response in patients with amblyopia.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo use highly precise spectral-domain optical coherence tomography (SD-OCT) to determine whether there were structural abnormalities in the layers of different regions of the fovea in children with anisometropic amblyopia.
methodsEighteen children (mean age 7.8 years old; range 5-11 years) with unilateral anisometropic amblyopia and 18 age-matched control subjects participated. Foveal thickness was measured with an enhanced depth imaging system, SD-OCT and segmented into layers using custom developed software. The thickness of each layer of the fovea was compared among amblyopic eyes, fellow eyes and control eyes with optical magnification correction for axial length and statistical correction for age and sex.
resultsThe total thickness and each intra-ocular layer of the central fovea were the same for each group. However, the amblyopic eyes were significantly thicker than the normal control eyes in 2 of 4 quadrants of the peripheral retina. Exploring intra-retinal layers in these two quadrants, the nasal nerve fiber layer (NFL) and inferior inner nuclear layer (INL)were significantly thicker in amblyopic eyes than in control eyes (p = 0.01 and 0.012, respectively, by ANCOVA).
conclusionThe SD-OCT data revealed marginal differences in some foveal layers at peripheral locations and indicated that structural differences might exist between individuals with amblyopia and visually normal control subjects. However, the differences were scattered and represented no identifiable pattern. More studies with large samples and precise locations of the retinal layers must be performed to extend the present results.
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