ArticlePloS one2017
Phenotypic and molecular characterization of antimicrobial resistance in Enterobacter spp. isolates from companion animals in Japan.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Antimicrobial Resistance in Veterinary Bacterial Pathogens: Resistance Patterns, Zoonotic Risks and One Health Implications.Pathogens (Basel, Switzerland) · 2026Review
- Whole-Genome Sequencing Reveals Heterogeneous Resistance Profiles and Selected Mobile Genetic Elements in Ecuadorian ClinicalAntibiotics (Basel, Switzerland) · 2026Article
- Prevalence and Antimicrobial Resistance Profiles ofAntibiotics (Basel, Switzerland) · 2026Article
- Distinct molecular epidemiology of resistances to extended-spectrum cephalosporins and carbapenems in Enterobacter hormaechei in cats and dogs versus horses in France.The Journal of antimicrobial chemotherapy · 2025Article
- Bloodstream infection with NDM-1/5Frontiers in cellular and infection microbiology · 2025Article
- Prevalence and antimicrobial resistance of Enterobacteriaceae in the north of Kazakhstan.Open veterinary journal · 2024Article
- Identification and Genomic Analyses of a Multidrug Resistant Avian PathogenicTransboundary and emerging diseases · 2024Article
- Molecular characterization and in-depth genome analysis of Enterobacter sp. S-16.Functional & integrative genomics · 2023Article
- In vitro efficacy of cephamycins against multiple extended-spectrum β-lactamase-producing Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae isolates from dogs and cats.The Journal of veterinary medical science · 2023Article
- The differential plasma and ruminal metabolic pathways and ruminal bacterial taxa associated with divergent residual body weight gain phenotype in crossbred beef steers.Translational animal science · 2023Article
- Emergence of a Novel Lineage and Wide Spread of aAntibiotics (Basel, Switzerland) · 2022Article
- Current status and future perspective of antimicrobial-resistant bacteria and resistance genes in animal-breeding environments.The Journal of veterinary medical science · 2022Review
- First Case Report of Detection of Multidrug-ResistantMicroorganisms · 2022Article
- Antimicrobial resistance of Escherichia coli, Enterobacter spp., Klebsiella pneumoniae and Enterococcus spp. isolated from the feces of giant panda.BMC microbiology · 2022Article
- Colistin Susceptibility in Companion Animal-DerivedFrontiers in cellular and infection microbiology · 2022Article
- Complete Genome Sequence of anMicrobiology resource announcements · 2021Article
- Complete Genome Sequence of anMicrobiology resource announcements · 2021Article
- Carbapenem-resistant Enterobacter cloacae complex in a tertiary Hospital in Northeast China, 2010-2019.BMC infectious diseases · 2021Article
- Assessment of animal diseases caused by bacteria resistant to antimicrobials: Dogs and cats.EFSA journal. European Food Safety Authority · 2021Article
- Dissemination of Extended-Spectrum-β-Lactamase-ProducingAntimicrobial agents and chemotherapy · 2021Article
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of antimicrobial resistance among Enterobacter spp., including resistance to extended-spectrum cephalosporins (ESC), is of great concern in both human and veterinary medicine. In this study, we investigated the prevalence of antimicrobial resistance among 60 isolates of Enterobacter spp., including E. cloacae (n = 44), E. aerogenes (n = 10), and E. asburiae (n = 6), from clinical specimens of dogs and cats from 15 prefectures in Japan. Furthermore, we characterized the resistance mechanisms harbored by these isolates, including extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR); and assessed the genetic relatedness of ESC-resistant Enterobacter spp. strains by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Antimicrobial susceptibility testing demonstrated the resistance rates to ampicillin (93.3%), amoxicillin-clavulanic acid (93.3%), cefmetazole (93.3%), chloramphenicol (46.7%), ciprofloxacin (43.3%), tetracycline (40.0%), ceftazidime (33.3%), cefotaxime (33.3%), trimethoprim/sulfamethoxazole (28.3%), gentamicin (23.3%), and meropenem (0%). Phenotypic testing detected ESBLs in 16 of 18 ESC-resistant E. cloacae isolates but not in the other species. The most frequent ESBL was CTX-M-15 (n = 8), followed by SHV-12 (n = 7), and CTX-M-3 (n = 1). As for AmpC β-lactamases, CMY-2 (n = 2) and DHA-1 (n = 2) were identified in ESC-resistant E. cloacae strains with or without ESBLs. All of the ESC-resistant E. cloacae strains also harbored one or two PMQRs, including qnrB (n = 15), aac(6')-Ib-cr (n = 8), and qnrS (n = 2). Based on MLST and PFGE analysis, E. cloacae clones of ST591-SHV-12, ST171-CTX-M-15, and ST121-CTX-M-15 were detected in one or several hospitals. These results suggested intra- and inter-hospital dissemination of E. cloacae clones co-harboring ESBLs and PMQRs among companion animals. This is the first report on the large-scale monitoring of antimicrobial-resistant isolates of Enterobacter spp. from companion animals in Japan.
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