ArticlePloS one2017
MCPIP1, alias Regnase-1 binds and cleaves mRNA of C/EBPβ.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- MCPIP3/Regnase-3 binds 14-3-3 proteins and contributes to the regulation of the cell cycle in human immortalized keratinocytes.Scientific reports · 2025Article
- The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis.Cell communication and signaling : CCS · 2025Article
- MCPIP1 modulates the miRNA‒mRNA landscape in keratinocyte carcinomas.Journal of experimental & clinical cancer research : CR · 2024Article
- In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.GeroScience · 2024Article
- Colonic Coffee Phenols Metabolites, Dihydrocaffeic, Dihydroferulic, and Hydroxyhippuric Acids Protect Hepatic Cells from TNF-α-Induced Inflammation and Oxidative Stress.International journal of molecular sciences · 2023Article
- Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma.Journal of experimental & clinical cancer research : CR · 2021Article
- Deletion of Mcpip1 in Mcpip1Biochimica et biophysica acta. Molecular basis of disease · 2021Article
- TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.Cancer science · 2021Article
- MCPIP1 ribonuclease can bind and cleaveRNA biology · 2021Article
- Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism.Cellular and molecular life sciences : CMLS · 2020Article
- Activity of MCPIP1 RNase in tumor associated processes.Journal of experimental & clinical cancer research : CR · 2019Review
- MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.Cell death & disease · 2019Article
- Aggregation of Human Trophoblast Cells into Three-Dimensional Culture System Enhances Anti-Inflammatory Characteristics through Cytoskeleton Regulation.International journal of molecular sciences · 2018Article
- Substrate specificity of human MCPIP1 endoribonuclease.Scientific reports · 2018Article
- Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CCAAT/enhancer-binding protein beta (C/EBPβ) is a transcription factor controlling a broad range of genes essential for homeostasis, including genes related to immune functions, inflammation, metabolism and growth. Monocyte chemoattractant protein-1-induced protein 1 (MCPIP1) also called as Regnase-1 is an RNase and has been shown to decrease the stability of short-lived transcripts coding for inflammation-related proteins, including IL-1β, IL-6, IL-2, IL-8, IL-12b, IER-3, c-Rel. We found previously that the half-life of the C/EBPβ transcript is regulated by MCPIP. To understand the mechanism driving down-regulation of C/EBPβ by MCPIP1, we applied an in vitro cleavage assay, followed by a luciferase-reporter assay and RNA immunoprecipitation (RIP). We demonstrated that MCPIP1 recognizes regions of the 3'UTR of C/EBPβ mRNA and promotes its decay by introducing direct endonucleolytic cleavage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.