Trial reportPloS one2017
A randomized clinical trial in preterm infants on the effects of a home-based early intervention with the 'CareToy System'.
Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01990183 (CareToy - A Modular Smart System for Infants' Rehabilitation at Home Based on Mechatronic Toys), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CareToy - A Modular Smart System for Infants' Rehabilitation at Home Based on Mechatronic Toys
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early Intervention for Children With Developmental Disabilities and Their Families via Telehealth: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- A systematic review of observational, naturalistic, and neurophysiological outcome measures of nonpharmacological interventions for autism.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022Pooled it
- Home based early intervention with CareToy-Revised in infants with early brain injury: a randomized controlled trial.Frontiers in medicine · 2026Trial
- Early developmental support for preterm infants based on exploratory behaviors: A parallel randomized controlled study.Brain and behavior · 2023Trial
- Effectiveness of the home-based training program Tele-UPCAT (Tele-monitored UPper Limb Children Action Observation Training) in unilateral cerebral palsy: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2023Trial
- Early visual training and environmental adaptation for infants with visual impairment.Developmental medicine and child neurology · 2021Trial
- A home-based, post-discharge early intervention program promotes motor development and physical growth in the early preterm infants: a prospective, randomized controlled trial.BMC pediatrics · 2021Trial
- The Coping with and Caring for Infants with Special Needs intervention was associated with improved motor development in preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2021Trial
- Effects on Parental Stress of Early Home-Based CareToy Intervention in Low-Risk Preterm Infants.Neural plasticity · 2019Trial
- Telehealth Delivery of the Homeostasis-Enrichment-Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study.Journal of medical Internet research · 2026Article
- A Systematic Review of Neurodevelopmental Tools for Preterm Infants During Infancy: Mapping the Components Across Infant Age Quarters.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025Review
- Early Intervention Including an Active Motor Component in Preterms with Varying Risks for Neuromotor Delay: A Systematic Review and Narrative Synthesis.Journal of clinical medicine · 2025Review
- Effects of the HEP® (Homeostasis-Enrichment-Plasticity) Approach in preterm infants with increased developmental risk: a randomized controlled study.Frontiers in pediatrics · 2025Article
- Sitting Acquisition and Early Communication Development: Are There Associations in Very Preterm Infants at Six Months of Corrected Age?Children (Basel, Switzerland) · 2024Article
- The Homeostasis-Enrichment-Plasticity (HEPJournal of clinical medicine · 2024Article
- HEPChildren (Basel, Switzerland) · 2024Article
- Wearable accelerometers for measuring and monitoring the motor behaviour of infants with brain damage during CareToy-Revised training.Journal of neuroengineering and rehabilitation · 2023Article
- Motor Development Comparison between Preterm and Full-Term Infants Using Alberta Infant Motor Scale.International journal of environmental research and public health · 2023Article
- [Exploration of family rehabilitation model for children with scar contracture after hand burns].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CareToy system is an innovative tele-rehabilitative tool, useful in providing intensive, individualized, home-based, family-centred Early Intervention (EI) in infants. Our aim was to evaluate, through a Randomized Clinical Trial (RCT) study, the effects of CareToy intervention on early motor and visual development in preterm infants. 41 preterm infants (range age: 3.0-5.9 months of corrected age) were enrolled and randomized into two groups, CareToy and Standard Care. 19 infants randomized in CareToy group performed a 4-week CareToy program, while 22 allocated to control group completed 4 weeks of Standard Care. Infant Motor Profile (IMP) was primary outcome measure, Alberta Infant Motor Scale (AIMS) and Teller Acuity Cards were secondary ones. Assessments were carried out at baseline (T0) and at the end of CareToy training or Standard Care period (T1). T1 was the primary endpoint. After RCT phase, 17 infants from control group carried out a 4-week CareToy program, while 18 infants from the CareToy group continued with Standard Care. At the end of this phase, infants were re-assessed at T2. In RCT phase, delta IMP total score and variation and performance sub-domains were significantly higher (P<0.050) in CareToy group if compared to Standard Care group. Similar results were found for Teller Acuity Cards, while no differences between groups were found for AIMS. No differences were found in any outcome measure results (T2-T0), between infants who started CareToy training before or after one month of standard care. This RCT study confirms the results of a previous pilot study, indicating that CareToy system can provide effective home-based EI.
trial registrationThis trial has been registered at www.clinicaltrials.gov (Identifier NCT01990183).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.