ArticleLab animal2017
Stressed out: providing laboratory animals with behavioral control to reduce the physiological effects of stress.
Article in Lab animal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effects of vatinoxan and fentanyl on blood glucose concentrations and diuresis in male Wistar rats sedated with medetomidine and midazolam.BMC veterinary research · 2026Article
- Blood Sampling in Göttingen Minipigs-A Case Study of Two Standard Methods and Clicker Training as a Restraint-Free Alternative.Animals : an open access journal from MDPI · 2025Article
- Animal Models of Human Pathology: Revision, Relevance and Refinements.Biomedicines · 2024Article
- Consideration of the importance of measuring thermal discomfort in biomedical research.Trends in molecular medicine · 2023Review
- Attending veterinarians improve the research capability and psychological well-being of researchers in animal research institutes.Frontiers in veterinary science · 2023Article
- Identification of Rodent Husbandry Refinement Opportunities through Benchmarking and Collaboration.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Propofol Immersion As a Euthanasia Method for Adult Zebrafish (Comparative medicine · 2022Article
- Performance and Consistency of Circulating Warm Water Blankets for Rodents.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Toward more equal and mutual human-pet relations: Insights and possible solutions based on social psychological theories.Frontiers in veterinary science · 2022Review
- Experimental Applications and Factors Involved in Validating Thermal Windows Using Infrared Thermography to Assess the Health and Thermostability of Laboratory Animals.Animals : an open access journal from MDPI · 2021Review
- A Case Study on the Behavioural Effect of Positive Reinforcement Training in a Novel Task Participation Test in Göttingen Mini Pigs.Animals : an open access journal from MDPI · 2021Article
- Effects of Acrylic Tunnel Enrichment on Anxiety-Like Behavior, Neurogenesis, and Physiology of C57BL/6J Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.PLoS biology · 2020Article
- Putting advanced microscopy in the hands of biologists.Nature methods · 2019Article
- Effects of adaptation to handling on the circadian rhythmicity of blood solutes inAnimal models and experimental medicine · 2019Article
- Behavior of mice aboard the International Space Station.Scientific reports · 2019Article
- Sleeping through anything: The effects of unpredictable disruptions on mouse sleep, healing, and affect.PloS one · 2019Article
- Effects of Rodent Thermoregulation on Animal Models in the Research Environment.Comparative medicine · 2018Review
- Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response.Frontiers in immunology · 2018Review
- Introducing Therioepistemology: the study of how knowledge is gained from animal research.Lab animal · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory animals experience a large amount of environmental stress. An animal's environment can include both physiological and social stressors that may require an animal to adapt to maintain allostatic balance. For example, thermal stress can lead to changes in behavior, reproduction and immune function, which has been detrimental to cancer modeling in mice. Chronic uncontrollable stress is widely acknowledged for its negative alterations to physiology. However, there is a lack in the understanding of how the laboratory environment affects animal physiology and behavior, particularly as it relates to characteristics of the human disease being modeled. Given the evidence on how stressors affect physiology, it is clear that efforts to model human physiology in animal models must consider animal stress as a confounding factor. We present evidence illustrating that providing captive animals with control or predictability is the best way to reduce the negative physiological effects of these difficult-to-manage stressors.
Indexed as
Identifiers
28328902What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.