Observational studyMedicine2017
Oral microbiome in HIV-associated periodontitis.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Definitions used for a healthy periodontium-A systematic review.International journal of dental hygiene · 2020Pooled it
- Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA.PLoS pathogens · 2020Trial
- Characterizing Oral Microbiome and Periodontal Disease in Oral HPV-Positive (COMP-HPV) individuals with HIV: an observational longitudinal study protocol.BMC oral health · 2026Observational
- Interplay Between Oral Microbiota and Mouth Health in People Living With HIV Under Antiretroviral Therapy With or Without Periodontitis.International journal of dentistry · 2026Article
- Oral Microbiome and Inferred Functions Predict Kaposi's Sarcoma Progression.Journal of medical virology · 2025Article
- Oral Microbiota Dysbiosis in Male HIV Patients: Comparative Analysis of Candidiasis and HPV-Associated Lesions.Microorganisms · 2025Article
- Perceptions on causes and effects of common oral diseases among HIV-positive and HIV-negative adults in Kigali, Rwanda: a qualitative study.BMC oral health · 2025Article
- Crosstalk between human immunodeficiency virus infection and salivary bacterial function in men who have sex with men.Frontiers in cellular and infection microbiology · 2024Article
- Human immunodeficiency virus and oral microbiota: mutual influence on the establishment of a viral gingival reservoir in individuals under antiretroviral therapy.Frontiers in cellular and infection microbiology · 2024Review
- Total mouth photodynamic therapy mediated by red LED and porphyrin in individuals with AIDS.Lasers in medical science · 2022Article
- Evaluation of Association of Oral Bacterial Profile with HBV and HCV Infection and T Lymphocyte Level in HIV-Positive Patients.International journal of dentistry · 2022Article
- Alterations in the oral microbiome in HIV infection: causes, effects and potential interventions.Chinese medical journal · 2021Review
- The human oral virome: Shedding light on the dark matter.Periodontology 2000 · 2021Review
- Probiotic supplementation reduces inflammatory profiles but does not prevent oral immune perturbations during SIV infection.Scientific reports · 2021Article
- Boolean implication analysis unveils candidate universal relationships in microbiome data.BMC bioinformatics · 2021Article
- The Use of MALDI-TOF Mass Spectrometry to Analyze Commensal Oral Yeasts in Nursing Home Residents.Microorganisms · 2021Article
- Oral Microbiota Is Associated With Immune Recovery in Human Immunodeficiency Virus-Infected Individuals.Frontiers in microbiology · 2021Article
- The Microbiota Profile Analysis of Combined Periodontal-Endodontic Lesions Using 16S rRNA Next-Generation Sequencing.Journal of immunology research · 2021Article
- Differential Signature of the Microbiome and Neutrophils in the Oral Cavity of HIV-Infected Individuals.Frontiers in immunology · 2021Article
- The Underrated Salivary Virome of Men Who Have Sex With Men Infected With HIV.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 4 countries.
Funding
Abstract
HIV-associated periodontal diseases (PD) could serve as a source of chronic inflammation. Here, we sought to characterize the oral microbial signatures of HIV+ and HIV- individuals at different levels of PD severity.This cross-sectional study included both HIV+ and HIV- patients with varying degrees of PD. Two tooth, 2 cheek, and 1 saliva samples were obtained for microbiome analysis. Mothur/SILVADB were used to classify sequences. R/Bioconductor (Vegan, PhyloSeq, and DESeq2) was employed to assess overall microbiome structure differences and differential abundance of bacterial genera between groups. Polychromatic flow cytometry was used to assess immune activation in CD4 and CD8 cell populations.Around 250 cheek, tooth, and saliva samples from 50 participants (40 HIV+ and 10 HIV-) were included. Severity of PD was classified clinically as None/Mild (N), Moderate (M), and Severe (S) with 18 (36%), 16 (32%), and 16 (32%) participants in each category, respectively. Globally, ordination analysis demonstrated clustering by anatomic site (R2 = 0.25, P < 0.001). HIV status and PD severity showed a statistically significant impact on microbiome composition but only accounted for a combined 2% of variation. HIV+ samples were enriched in genera Abiotrophia, Neisseria, Kingella, and unclassified Neisseriaceae and depleted in Leptotrichia and Selenomonas. The Neisseria genus was consistently enriched in HIV+ participants regardless of sampling site and PD level. Immune markers were altered in HIV+ participants but did not show association with the oral microbiome.HIV-associated changes in oral microbiome result in subtle microbial signatures along different stages of PD that are common in independent oral anatomic sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.