SynthesisMedicine2017
Body mass index and the risk of low bone mass-related fractures in women compared with men: A PRISMA-compliant meta-analysis of prospective cohort studies.
Synthesis in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Socio-economic inequalities in fragility fracture incidence: a systematic review and meta-analysis of 61 observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Pooled it
- Missed Opportunities in Osteoporosis Prevention and Screening in Postmenopausal Women: Risk Profiles and AwarenessTurkish journal of pharmaceutical sciences · 2026Article
- Underweight in Young Adult Women as a Dynamic Nutritional State: Evidence from Four Complementary Longitudinal Methods.Nutrients · 2026Article
- Observational
- A Modeling Study for Hip Fracture Rates in Romania.Journal of clinical medicine · 2025Article
- Bone health in childhood low-grade glioma: an understudied problem.Endocrine connections · 2024Article
- Association between socioeconomic deprivation and bone health status in the UK biobank cohort participants.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Body mass index, height, and osteoporotic fracture risk in community-dwelling Japanese people aged 40-74 years.Journal of bone and mineral metabolism · 2024Article
- Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024Article
- Association between Wrist Circumference and Risk of Any Fracture in Adults: Findings from 15 Years of Follow-Up in the Tehran Lipid and Glucose Study.Journal of clinical medicine · 2022Article
- Dietary Acid Load Was Positively Associated with the Risk of Hip Fracture in Elderly Adults.Nutrients · 2022Article
- Prediction of vertebral fractures in cancer patients undergoing hormone deprivation therapies: Reliability of who fracture risk assessment tool (frax) and bone mineral density in real-life clinical practice.Journal of bone oncology · 2022Article
- Article
- Association Between Body Mass Index and Functional Outcomes in Elderly Patients with Extra-articular Distal Radius Fracture: A Prospective Observational Study.Indian journal of orthopaedics · 2021Article
- Prevalence and Associated Factors of Low Bone Mineral Density in the Femoral Neck and Total Hip in Axial Spondyloarthritis: Data from the CASTRO Cohort.Journal of clinical medicine · 2021Article
- Duration of Bisphosphonate Drug Holidays in Osteoporosis Patients: A Narrative Review of the Evidence and Considerations for Decision-Making.Journal of clinical medicine · 2021Review
- Alendronate Use and Risk of Type 2 Diabetes: A Nationwide Danish Nested Case-Control Study.Frontiers in endocrinology · 2021Article
- Animal models of disuse-induced bone loss: study protocol for a systematic review.Systematic reviews · 2020Article
- Falls and Fractures in Diabetes-More than Bone Fragility.Current osteoporosis reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBody mass index (BMI) is inconsistently associated with the progression of low bone mass-related fractures. We conducted a systematic review and meta-analysis to summarize the evidence regarding the relationship between BMI and the risk of fracture in men and women separately. Furthermore, we analyzed the association between BMI and fracture risk in women compared with men.
methodsPubMed, EmBase, and the Cochrane Library were searched up to November 2015 to identify prospective cohort studies of low bone mass-related fractures. Prospective cohort studies that reported effect estimates of fracture risk for different BMI categories compared to normal weight were included. Relative risk (RR) and the ratio of relative risk (RRR) were calculated using a random-effect model to measure the relationship between BMI and fracture risk.
resultsWe analyzed 37 cohorts (32 articles), which included a total of 506,004 women and 118,372 men; overall, 38,200 incident cases were reported. Overall, a lower BMI was not associated with fracture risk in men (RR: 1.50, 95% confidence interval [CI]: 1.00-2.26; P = 0.051) or women (RR: 1.25, 95% CI: 0.97-1.62; P = 0.083). Although a higher BMI might play a beneficial impact in men (RR: 0.80, 95% CI: 0.69-0.93; P = 0.003), it has little effect in women (RR: 0.91, 95% CI: 0.74-1.11; P = 0.343). In addition, an increase in BMI by 5 kg/m decreased the risk of fractures in men (RR: 0.90, 95% CI: 0.83-0.98; P = 0.017) and women (RR: 0.85, 95% CI: 0.81-0.89; P < 0.001). Finally, there was no evidence of a sex difference in the RR for fractures between participants with different BMI categories compared with those with normal BMI. Finally, gender did not affect the risk of fracture for any category of BMI values.
conclusionHigher BMI may affect the risk of fractures regardless of the sex. This association may be due to the interaction between the participants' BMI and their bone mass density.
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